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Understanding the role of beta-catenin for angiogenesis

Research Project

Project/Area Number 24790304
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

TERAI KENTA  東京大学, 分子細胞生物学研究所, 助教 (20616073)

Co-Investigator(Renkei-kenkyūsha) KASHIWADA Takeru  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsゼブラフィッシュ / 血管新生 / 次世代シークエンサー / ベータカテニン / 血管形成
Outline of Final Research Achievements

Angiogenesis is an essential event for animal development. Beta-catenin is a well-known molecule for regulating angiogenesis. Lack of beta-catenin in blood vessel cells cause vascular abnormality and poor development in mouse. However when and where beta-catenin is activated is not well known. To understand and visualize beta-catenin activity, we generated transgenic zebrafish which represents beta-catenin transcriptional activity in living fish.
By using the fish, we identified that beta-catenin activated cells during caudal vein plexuses formation. Furthermore, the activity of beta-catenin is positively regulated by Bone Morphogenetic Protein (BMP) dependent AnGiogenic factor with G patch and FHA domains 1 (AGGF1) expression. The activation of beta-catenin in CVP is dispensable for cell survival and cell differentiation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] β-Catenin-dependent transcription is central to Bmp-mediated formation of venous vessels.2015

    • Author(s)
      Kashiwada T, Fukuhara S (Co-corresponding author), Terai K, Tanaka T, Wakayama Y, Ando K, Nakajima H, Fukui H, Yuge S, Saito Y, Gemma A, Mochizuki N.
    • Journal Title

      Development

      Volume: 142 Pages: 497-509

    • DOI

      10.1242/dev.115576

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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