| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
It has become widely accepted that macrophages exhibit heterogeneity in the atherosclerotic plaques during the progression of atherosclerosis. Plaque-associated macrophages can undergo pro- (M1) and anti-inflammatory (M2) polarization depending on the inflammatory status.To clarify the roles of Nrf2 in atherogenesis, we used an ApoE and Nrf2 double KO mouse model. As a result, we have clarified the role of Nrf2 in the M1 macrophage cells during the development of atherosclerosis in late stage, which indicates that Nrf2 may influence the inflammatory reactions in the plaques. The paper containing these results was accepted for publication in FRBM.
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