Analysis of the effects of hypoxia inducible factor for tumor metastasis
| Project/Area Number |
24790308
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 分子腫瘍学 / 低酸素応答 / 血管内皮細胞 / がん微小環境 / がん転移 |
|---|
| Research Abstract |
Hypoxia inducible transcription factor (HIF) has various physiological functions. The results of the HIF functional analysis in vascular endothelial cells with tail vein injection metastasis model, we found that metastasis foci was reduced when transplanted into HIF-2alpah knockdown host mice. HIF-2alpa knockdown mice have low activities in HIF-2alpha in endothelial cells. Furthemore, HIF-3alpha acting on inhibitory to the hypoxic response is controlling to the inhibitory VE-cadherin expression in pulmonary vascular endothelial cells. We found the phenomenon that HIF-1apha is activated in compensatory when HIF-2alpha was reduced to a certain level below threshold.
|
Report
(3 results)
Research Products
(26 results)
-
-
[Journal Article] Deficiency of NOXl/nicotinamide adenine dinucleotide phosphate,reduced form oxidase leads to pulmonary vascular remodeling2014
Author(s)
Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C.
-
Journal Title
Arterioscler Thromb Vasc Biol
Volume: 34(1)
Pages: 110-119
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.2013
Author(s)
Fukuda S, Nagano M, Yamashita T, Kimura K, Tsuboi I, Salazar G, Ueno S, Kondo M, Kunath T, Oshika T, Ohneda O
-
Journal Title
Stem Cells.
Volume: 31
Pages: 2149-2161
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
