Functions of Mob1A/1B in development and oncogenesis
Project/Area Number |
24790319
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Kyushu University |
Principal Investigator |
NISHIO Miki 九州大学, 生体防御医学研究所, 助教 (10467897)
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Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Akira 九州大学, 生体防御医学研究所, 教授 (10311565)
ITAMI Satoshi 大阪大学, 大学院医学系研究科, 教授 (30136791)
MIZUNO Kensaku 東北大学, 大学院生命科学研究科, 教授 (70128396)
CHIBA Syuhei 大阪大学, 大学院生命科学研究科, 特任助教 (60572493)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 発癌 / Mob1 / シグナル伝達 / 発生 / 発がん / Mob |
Research Abstract |
The Hippo pathway is evolutionarily conserved, and the vertebrate Hippo pathway has been implicated in regulating cell contact inhibition, organ size, and tumorigenesis. The Mob1A/1B are the binding partners and strong co-activators of Lats kinases family, and the members of the Hippo pathway.However, the normal functions of Mob1A/1B proteins in vivo had been unknown.To define the functions of mammarian Mob1A/1B, we generated Mob1A and 1B null mutant mice. We showed Mob1A/1B double homozygous mutant mice died at gastrulation.Thus, Mob1A/B is essential for murine embryogenesis. Partially mutants developed a variety of tumors. Moreover, half of human trichilemmal carcinoma samples showed Mob1A/1B inactivation and YAP activation.These observations suggest that the loss of Hippo signaling molecules can be an important driver of cancer progression.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] The expression of PTEN in the development of mouse cochlear lateral wall.2014
Author(s)
Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Noguchi C, Katagi A, Nishio M, Suzuki A, Tokuda M.
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Journal Title
NEURO SCIENCE
Volume: 258
Pages: 263-9
DOI
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Peer Reviewed
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[Presentation] Functions of MOB1A/1B in murine lung
Author(s)
Kohei Ohtsubo, Miki Nishio, Yoichi Nakanishi, Akira Suzuki
Organizer
The 23rd Hot Spring Harbor International Symposium, Recent Advances in Stem Cell Biology
Place of Presentation
福岡
Related Report
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[Presentation] Functions of the Mob1A/1B in mice
Author(s)
Miki Nishio, Jia Wang, Takumi Morikawa, Kohei Otsubo, Yoko Toh, Hiroki Hikasa, Satoshi Itami, Keishu Sugimachi, Koshi Mimori, Akira Suzuki
Organizer
第72回日本癌学会学術総会
Place of Presentation
横浜
Related Report
Invited
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