Effects of lipoprotein lipase and apolipoprotein AII on exercise regimen for obesity.

• Project/Area Number: 24790320
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Akita University (2014); Saga University (2012-2013)
• Principal Investigator: NISHIJIMA Kazutoshi 秋田大学, バイオサイエンス教育・研究センター, 准教授 (70435874)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 遺伝子導入ウサギ / アポリポ蛋白AII / リポ蛋白リパーゼ / メタボリック症候群 / 運動 / リポ蛋白りパーゼ

Outline of Final Research Achievements

Lactate threshold in apolipoprotein (apo)AII transgenic (Tg) rabbit tended to be lower than in lipoprotein lipase (LPL)-Tg and wild-type rabbits.
Within intravenous glucose tolerance test, decreasing rate of blood glucose level was high in LPL-Tg rabbit and low in apoAII-Tg in comparison to wild-type rabbit. After feeding high fat diet and exercise loading, the decreasing rate of blood glucose level in apoAII-Tg rabbit was lower than that in LPL-Tg and wild-type rabbits.
These results would be caused by transferred apoAII or LPL gene.