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Biological and pathological function of Storkhead-protein 1

Research Project

Project/Area Number 24790329
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionKanazawa Medical University

Principal Investigator

KANASAKI Megumi  金沢医科大学, 医学部, 助教 (50599355)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsStox1 / 糖尿病性腎症 / 腎線維化 / 糖尿病生腎症 / Stox / 糖尿病 / 尿アルブミン
Outline of Final Research Achievements

Transcription factor Storkhead-protein 1 (Stox1) localize on the chromosome 10q22 which has been reported as a responsible site of type 2 diabetic nephropathy and severe hypertension. Applicants created Stox1 knockout mice and reported first in the world. When compared streptozotocin induced diabetic model of our Stox1 knockout mice to it’s littermate wild type mice, in SV129 strain Stox1 knockout mice shows significantly more albuminuria and more histologically severe renal tublointerstitial fibrosis, whereas in C57Bl6 strain obvious phenotype change were not detected between the two genotypes. We showed that Stox1 contributes to the development of renal failure in chronic hyperglycemia state and also that there is a difference by a mouse strain in the role of Stox1 for development of diabetic renal vascular complications.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results)

  • [Journal Article] Interactions of DPP-4 and integrin β1 influences endothelial-to mesenchymal transition.2015

    • Author(s)
      Shi S, Srivastava SP, Kanasaki M, He J, Kitada M, Nagai T, Nitta K, Takagi S, Kanasaki K, Koya D.
    • Journal Title

      Kidney Int.

      Volume: - Issue: 3 Pages: 479-489

    • DOI

      10.1038/ki.2015.103

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The biological significance of angiotensisn-converting enzyme inhibition to combat kidney fibrosis2015

    • Author(s)
      Nagai T, Nitta K, Kanasaki M, Koya D, Kanasaki K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 19 Issue: 1 Pages: 65-74

    • DOI

      10.1007/s10157-014-1000-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition2014

    • Author(s)
      Takako Nagai, Megumi Kanasaki, Swayam Prakash Srivastava, Yuka Nakamura, Yasuhito Ishigaki, Munehiro Kitada, Sen Shi, Keizo Kanasaki, Daisuke Koya
    • Journal Title

      BioMed Research International

      Volume: 2014 Pages: 696475-696475

    • DOI

      10.1155/2014/696475

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Linagriptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabeticmice by inhibiting endothelial-to mesenchymal transition in a therapeutic regimen.2014

    • Author(s)
      Kanasaki K, Shi S, Kanasaki M, He J, Nagai T, Nakamura Y, Ishigaki Y, Kitada M, Srivastava SP, Koya D.
    • Journal Title

      Diabetes.

      Volume: 63 Issue: 6 Pages: 2120-2131

    • DOI

      10.2337/db13-1029

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Specific Activation of KRas G12D Allele in the Bladder Urothelium Results inLung Alveolar and Vascular Defects2014

    • Author(s)
      Ayala de la Pena F,Kanasaki K, Kanasaki M,Vong S, Rovira C,Kalluri R
    • Journal Title

      PLos One

      Volume: 9 Pages: 1-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Linaglipton-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to mesenchymal transition in a therapeutic regimen2014

    • Author(s)
      Kanasaki K,Shi S,Kanasaki M,He J,Nagai T,Nakamura Y,Ishigaki Y,Kitada M,Srivastava SP,Koya D.
    • Journal Title

      Diabetes

      Volume: 13 Pages: 1-40

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiogenic defects in preeclampsia: What is known and how are such defects relevant to preeclampsia pathogenesis?2014

    • Author(s)
      Keizo Kanasaki, Megumi Kanasaki
    • Journal Title

      Hypertension Research in Pregnancy

      Volume: 1(2) Pages: 57-65

    • NAID

      130004638238

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The biological consequence of obesity on the kidney2013

    • Author(s)
      Kanasaki K,Kitada M,Kanasaki M,Koya D.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 4 Pages: 1-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules.2013

    • Author(s)
      Xu L, Kanasaki M, He J, Kitada M, Nagao K, Jinzu H, Noguchi Y, Maegawa H, Kanasaki K, Koya D.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1832(10) Issue: 10 Pages: 1605-1612

    • DOI

      10.1016/j.bbadis.2013.05.003

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Loss of b1-Integrin from Urothelium Results in Overactive Bladder and Incontinence in Mice2013

    • Author(s)
      Keizo Kanasaki, Weiqun Yu, Maximilian von Bodungen, John D. Larigakis, Megumi Kanasaki, Francisco Ayala de la Pena, Raghu Kalluri, Warren G. Hill
    • Journal Title

      FASEB J

      Volume: 27 Issue: 5 Pages: 1950-61

    • DOI

      10.1096/fj.12-223404

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Loss of &b1-Integrin from Urothelium Results in Overactive Bladder and Incontinence in Mice: A Mechanosensory rather than Structural Phenotype2013

    • Author(s)
      Keizo Kanasaki
    • Journal Title

      FASEB J

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The biological consequence of obesity on the kidney2013

    • Author(s)
      Keizo Kanasaki
    • Journal Title

      Nephrology Dialysis and Transplantation

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three ileus cases associated with the use of DPP-4 inhibitors in diabetic patients2013

    • Author(s)
      Keizo Kanasaki
    • Journal Title

      Journal of Diabetes Investigation

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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