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pathophysiological analysis of autophagic substrate Nbr1.

Research Project

Project/Area Number 24790332
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

SOU Yu-shin  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 (60576221)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsオートファジー / Nbr1 / nbr1 / p62
Research Abstract

To investigate a physiology of the Nbr1 metabolism, accumulation of Nbr1 and the affect to the liver, we created liver specific Atg7 and Nbr1-double deficient mice, and performed biochemical and morphological analysis.In liver specific Nbr1 knockout mice, the abnormality is not recognized. Simultaneous loss of Atg7 and Nbr1 in the liver cause hepatomegaly and liver dysfunction. It is shown that Loss of Nbr1 has few impacts on liver pathology in Atg7-deficient livers.
Further analysis is needed to clarify the pathophysiological role of Nbr1 in Atg7-p62 double knockout tissues.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Phosphorylation of p62 activates the Keap1 - Nrf2 pathway during selective autophagy2014

    • Author(s)
      ①Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M
    • Journal Title

      Mol Cell

      Volume: 51 Pages: 618-31

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy2014

    • Author(s)
      ②Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 446 Pages: 309-15

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane2014

    • Author(s)
      ③Uemura T, Yamamoto M, Kametaka A, Sou YS, Yabashi A, Yamada A, Annoh H, Kametaka S, Komatsu M, Waguri S
    • Journal Title

      Mol Cell Biol

      Volume: 34 Pages: 1695-706

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy.2014

    • Author(s)
      Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 446 Issue: 1 Pages: 309-315

    • DOI

      10.1016/j.bbrc.2014.02.093

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013

    • Author(s)
      Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
    • Journal Title

      Mol Cell

      Volume: 51 Issue: 5 Pages: 618-631

    • DOI

      10.1016/j.molcel.2013.08.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] オートファジー選択的基質p62およびNbr1の病態生理的意義2013

    • Author(s)
      曽友深,和栗聡,田中啓二,小松雅明
    • Organizer
      第1回オートファジー班会議(ポスター発表)
    • Year and Date
      2013-12-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Phenotypic analysis of liver specific Atg7 Nbr1 - double knockout mice2012

    • Author(s)
      ②Yu-shin Sou, Satoshi Waguri, Keiji Tanaka, and Masaaki Komatsu
    • Organizer
      6th International symposium on Autophagy(ポスター発表)
    • Year and Date
      2012-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Phenotypic analysis of liver specific Atg7 Nbr1-double knockout mice2012

    • Author(s)
      Yu-shin Sou, Satoshi Waguri, Keiji Tanaka and Masaaki Komatsu
    • Organizer
      6th International Symposium on Autophagy 2012
    • Place of Presentation
      沖縄 ブセナテラス
    • Related Report
      2012 Research-status Report
  • [Presentation] オートファジー選択的基質による凝集体形成制御機構

    • Author(s)
      曽 友深、和栗 聡、 Caroline A Whitehouse、小松 雅明
    • Organizer
      第23回日本生体防御学会学術総会
    • Place of Presentation
      東京 品川区総合区民会館
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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