The functional analysis of histone methyltransferase in obesity

• Project/Area Number: 24790334
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: Juntendo University (2013); The University of Tokyo (2012)
• Principal Investigator: FUJII Tomoaki 順天堂大学, 医学(系)研究科(研究院), 研究員 (10511420)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: エピジェネティクス / ヒストンメチルトランスフェラーゼ / 肥満

Research Abstract

Accumulating findings show that histone methyltransferases are implicated in obesity.To investigate the role of Smyd family genes encode histone methyltransferase, we generated and analyzed Smyd2/3double knockout mice. The mice exhibited obesity related phenotypes, an increase in body weight and abnormal accumulation of fat. These results suggest that Smyd2 and Smyd3 play a significant role in fat accumulation and adipocyte differentiation.

Research Products

• [Journal Article] Identification of Two Wnt - Responsive Elements in the Intron of RING Finger Protein 43 (RNF43) Gene (2014)
  • Author(s): ①Takahashi, N., Yamaguchi, K., Ikenoue, T., Fujii, T., Furukawa, Y
  • Journal Title: PLoS ONE Volume: 9(1)
• [Journal Article] Overexpression of Cohesion Establishment Factor DSCC1 through E2F in Colorectal Cancer (2014)
  • Author(s): ②Yamaguchi, K., Yamaguchi, R., Takahashi, N., Ikenoue, T., Fujii, T., Shinozaki, M., Tsurita, G., Hata, K., Niida, A., Imoto, S., Miyano, S., Nakamura, Y., Furukawa, Y
  • Journal Title: PLoS ONE Volume: 9(1)
• [Journal Article] Identification of Two Wnt-Responsive Elements in the Intron of RING Finger Protein 43 (RNF43) Gene (2014)
  • Author(s): .Takahashi,N., Yamaguchi,K., Ikenoue,T., Fujii,T., Furukawa,Y.
  • Journal Title: PLoS ONE Volume: 9(1)
  • Peer Reviewed
• [Journal Article] Overexpression of Cohesion Establishment Factor DSCC1 through E2F in Colorectal Cancer. (2014)
  • Author(s): Yamaguchi,K., Yamaguchi,R., Takahashi,N., Ikenoue, T., Fujii,T., Shinozaki, M., Tsurita, G., Hata, K., Niida, A., Imoto, S., Miyano, S., Nakamura, Y., Furukawa, Y.
  • Journal Title: PLoS ONE Volume: 9(1)
  • Peer Reviewed
• [Presentation] 患者大腸癌組織片の移植モデルにおける顕著な肝臓および肺への転移形成 (2013)
  • Author(s): 水越幸輔,岡澤裕,小見山博光,藤井智明,伊藤恭彦,五藤倫敏,垣生園子,樋野興夫,坂本一博,折茂彰
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィッコ横浜
  • Year and Date: 2013-10-05
• [Presentation] オートファジー不全は恒常性活性化型Kras変異に起因するマウス膵腫瘍の発生を促進する (2013)
  • Author(s): 池上恒雄,今井光穂,藤井智明,山口貴世志,松原大祐,伊地知秀明,立石敬介,小池和彦,古川洋一
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィッコ横浜
  • Year and Date: 2013-10-03
• [Presentation] 乳癌における癌間質内Jagged1 - Notch3シグナル (2013)
  • Author(s): 藤井智明,堀本義哉,Ahmet Acar,伊藤恭彦,斎藤光江,樋野興夫,折茂彰
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィッコ横浜
  • Year and Date: 2013-10-03
• [Presentation] オートファジー不全は恒常活性化型Kras変異に起因するマウス膵腫瘍の発生を促進する (2013)
  • Author(s): 池上恒雄、今井光穂、藤井智明、山口貴世志、松原大祐、伊地知秀明、立石敬介、小池和彦、古川洋一
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィッコ横浜
• [Presentation] 乳癌における癌間質内Jagged1‐Notch3 シグナル (2013)
  • Author(s): 藤井智明 堀本義哉 Ahmet Acar伊藤恭彦、齊藤光江、樋野興夫、折茂彰
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィッコ横浜
• [Presentation] オートファジー不全はマウスの膵腫瘍の発生を促進する (2012)
  • Author(s): 今井光穂,池上恒雄,藤井智明,磯村好洋,小池和彦,古川洋一
  • Place of Presentation: さっぽろ芸文館
  • Year and Date: 2012-12-13
• [Presentation] オートファジー不全はマウスの膵腫瘍の発生を促進する
  • Author(s): 今井光穂 池上恒雄 藤井智明 磯村好洋 小池和彦 古川洋一
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌・さっぽろ芸文館