Genetic analysis of sarcoidosis in a multi-ethnic cohort
Project/Area Number |
24790338
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Human genetics
|
Research Institution | Yokohama City University |
Principal Investigator |
MEGURO Akira 横浜市立大学, 医学(系)研究科(研究院), 特任講師 (60508802)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | サルコイドーシス / 遺伝子 |
Research Abstract |
Sarcoidosis is a chronic multi-systemic inflammatory disorder. In this study, to identify susceptibity genes of sarcoidosis, we performed a genome-wide association study of sarcoidosis using Japanese and Czech populations. This study identified a genetic region showing a genome-wide significance (P<5E-8).
|
Report
(3 results)
Research Products
(45 results)
-
-
-
-
-
-
[Journal Article] Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.2013
Author(s)
Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Meguro A, Mizuki N, et al
-
Journal Title
Am J Hum Genet
Volume: 93(2)
Issue: 2
Pages: 264-277
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease.2013
Author(s)
Kirino Y, Zhou Q, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Ugurlu S, Erer B, Abaci N, Ustek D, Meguro A, Ueda A, Takeno M, Inoko H, Ombrello MJ, Satorius CL, Maskeri B, Mullikin JC, Sun HW, et al
-
Journal Title
Proc Natl Acad Sci U S A
Volume: 110(20)
Issue: 20
Pages: 8134-8139
DOI
Related Report
Peer Reviewed
-
[Journal Article] Investigation of the association between Toll-like receptor 9 gene polymorphisms and sarcoidosis in Japanese patients.2013
Author(s)
Yotsumoto S, Meguro A, Ishihara M, Uemoto R, Ota M, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
-
Journal Title
Ocul Immunol Inflamm
Volume: 21(3)
Issue: 3
Pages: 234-236
DOI
Related Report
Peer Reviewed
-
[Journal Article] Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population2013
Author(s)
⑩Mikami T, Meguro A, Teshigawara T, Takeuchi M, Uemoto R, Kawagoe T, Nomura E, Asukata Y, Ishioka M, Iwasaki M, Fukagawa K, Konomi K, Shimazaki J, Nishida T, Mizuki N
-
Journal Title
Mol Vis
Volume: 19
Pages: 845-851
URL
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population.2013
Author(s)
Mikami T, Meguro A, Teshigawara T, Takeuchi M, Uemoto R, Kawagoe T, Nomura E, Asukata Y, Ishioka M, Iwasaki M, Fukagawa K, Konomi K, Shimazaki J, Nishida T, Mizuki N
-
Journal Title
Mol Vis
Volume: 19
Pages: 845-851
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-