Approach to identify genetic susceptibility to lung adenocarcinoma with EGFR mutation
Project/Area Number |
24790340
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human genetics
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
SHIRAISHI Kouya 独立行政法人国立がん研究センター, 研究所, 研究員 (80609719)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 肺腺がん / 遺伝子多型 / 全ゲノム関連解析 / 肺腺がん感受性遺伝子の同定 / 国際研究者交流:アメリカ / 国際情報交換 |
Research Abstract |
Advanced in genome research, it has become clear that the frequency of ADC with EGFR mutation was different between Asian and Caucasian. Therefore, genetic factors involved in susceptibility to ADC with EGFR mutation might be different by ethnicity or genetic background. To identify new susceptibility loci in ADC with EGFR mutation, we performed a genome-wide association study of ADC with EGFR mutation consisted of 663 cases from National cancer center hospital and 4,365 controls from Bio-bank Japan. In the GWAS, previously reported loci with ADC risk (TERT, TP63, BPTF and BTNL2) were also associated with risk for ADC with EGFR mutation. We detected EGFR mutation in DNA samples extracted from lung cancer tissues using HRMA. Further studies of putative susceptibility loci in several replication sets will need to identify new susceptibility to ADC with EGFR mutation.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.2013
Author(s)
Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H and Yamamoto M.
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Journal Title
Mol Cell Biol
Volume: 33
Issue: 12
Pages: 2402-2412
DOI
Related Report
Peer Reviewed
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[Journal Article] A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population2012
Author(s)
Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
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Journal Title
Nature Genetics
Volume: 44
Issue: 8
Pages: 900-903
DOI
Related Report
Peer Reviewed
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[Presentation] Genetic factors related with lung adenocarcinoma2013
Author(s)
Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
Organizer
日本癌学会
Place of Presentation
横浜
Related Report
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[Presentation] Genetic factors related with lung adenocarcinoma2013
Author(s)
Kouya Shiraishi, Hideo Kunitoh, Yataro Daigo, Atsushi Takahashi, Koichi Goto, Hiromi Sakamoto, Sumiko Ohnami, Yoko Shimada, Kyota Ashikawa, Akira Saito, Shun-ichi Watanabe, Koji Tsuta, Naoyuki Kamatani, Teruhiko Yoshida, Yusuke Nakamura, Jun Yokota, Michiaki Kubo , Takashi Kohno
Organizer
日本癌学会
Place of Presentation
横浜・パシフィコ横浜
Related Report
Invited
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[Presentation] A genome - wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population2012
Author(s)
Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
Organizer
An AACR Special Conference on Post - GWAS horizons in molecular epidemiology
Place of Presentation
Hollywood, FL, USA
Related Report
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[Presentation] A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population2012
Author(s)
Kouya Shiraishi, Hideo Kunitoh Yataro Daigo, Atsushi Takahashi, Koichi Goto, Hiromi Sakamoto, ..., Teruhiko Yoshida, Yusuke Nakamura, Jun Yokota, Michiaki Kubo, Takashi Kohno.
Organizer
An AACR Special Conference on Post-GWAS horizons in molecular epidemiology
Place of Presentation
Hollywood, FL, USA
Related Report
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