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Role of microRNA in cystic fluid of ovarian clear cell adenocarcinoma

Research Project

Project/Area Number 24790349
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionThe University of Tokyo

Principal Investigator

MAEDA Daichi  東京大学, 医学部附属病院, 助教 (30585500)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords卵巣明細胞腺癌 / 嚢胞内容液 / マイクロRNA / 卵巣 / 国際情報交換
Research Abstract

We succeeded in evaluating microRNAs in the cystic fluid of ovarian neoplasm. miR-21 and miR-141 were more abundant in the cystic fluid of ovarian clear cell adenocarcinoma in comparison with their precursor lesion, endometriotic cyst. This finding suggests that miR-21 and miR-141 may play a significant role in the tumorigenesis of ovarian clear cell adenocarcinoma. Furthermore, they may be useful diagnostic markers.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 2 results) Presentation (7 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynecologic malignancies2014

    • Author(s)
      Wu RC, Ayhan A, Maeda D, Kim KR, Clarke BA, Shaw P, Herman Chui M, Rosen B, Shih IM, Wang TL
    • Journal Title

      J Pathol

      Volume: 232(4) Pages: 473-81

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pathogenesis of the Endometriosis-Related Ovarian Neoplasms2014

    • Author(s)
      Maeda D
    • Journal Title

      Curr Obstet Gynecol Rep

      Volume: 3 Pages: 1-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.2014

    • Author(s)
      Wu RC, Ayhan A, Maeda D, Kim KR, Clarke BA, Shaw P, Chui MH, Rosen B, Shih IeM, Wang TL.
    • Journal Title

      J Pathol.

      Volume: 232(4) Issue: 4 Pages: 473-81

    • DOI

      10.1002/path.4315

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of the Endometriosis-Related Ovarian Neoplasms2014

    • Author(s)
      Maeda D.
    • Journal Title

      Curr Obstet Gynecol Rep.

      Volume: 3 Issue: 1 Pages: 1-8

    • DOI

      10.1007/s13669-013-0073-4

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary2013

    • Author(s)
      Koso T, Matsusaka K, Tanaka M, Arimoto T, Oda K, Kawana K, Yano T, Fujii T, Fukayama M, Halimi SA, Maeda D, Shinozaki-Ushiku A
    • Journal Title

      Histopathology

      Volume: 63(4) Pages: 534-44

    • Related Report
      2013 Final Research Report
  • [Journal Article] Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary.2013

    • Author(s)
      Halimi SA, Maeda D, Shinozaki-Ushiku A, Koso T, Matsusaka K, Tanaka M, Arimoto T, Oda K, Kawana K, Yano T, Fujii T, Fukayama M
    • Journal Title

      Histopathology

      Volume: 63 Issue: 4 Pages: 534-544

    • DOI

      10.1111/his.12182

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maeda D, Shih IeM.2013

    • Author(s)
      Pathogenesis and the role of ARID1A mutation in endometriosis-related ovarian neoplasms.
    • Journal Title

      Adv Anat Pathol.

      Volume: 20(1) Issue: 1 Pages: 45-52

    • DOI

      10.1097/pap.0b013e31827bc24d

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Presentation] Utility of claudin-18 immunohistochemistry for detecting benign endocervical glandular lesions exhibiting gastric differentiation (so-called lobular endocervical glandular hyperplasia)2014

    • Author(s)
      Maeda D, Mikami Y and Fukayama M
    • Organizer
      The 103rd USCAP annual meeting
    • Place of Presentation
      San Diego, USA[Poster presentation]
    • Year and Date
      2014-03-05
    • Related Report
      2013 Final Research Report
  • [Presentation]2013

    • Author(s)
      Maeda D and Fukayama M
    • Organizer
      The 17th Taiwan-Japan-Korea Joint Meeting for Gynecological Pathology,Slide conference, Session 2, J-2
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] A case of endocervical adenocarcinoma in association with benign gastric-type glandular proliferation2013

    • Author(s)
      Maeda D and Fukayama M
    • Organizer
      The 8^<th > Asia Pacific IAP congress, Slide seminar A solid and cystic ovarian mass in 33-year-old female
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] 現行WHO 分類(第3 版:2003 年)の枠組みと問題点2013

    • Author(s)
      前田大地
    • Organizer
      第54回婦人科腫瘍学会 教育シンポジウム1:卵巣腫瘍の病理
    • Place of Presentation
      東京 ホテル グランパシフィック LE DAIBA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Claudin-18 and MUC5AC Immunohistochemistry Is Useful for Distinction between Primary Ovarian Mucinous Adenocarcinoma and Metastatic Colorectal Carcinoma Involving the Ovary2013

    • Author(s)
      Halimi SA, Maeda D, Fukayama M.
    • Organizer
      The 102th USCAP annual meeting
    • Place of Presentation
      Baltimore, U.S.A.
    • Related Report
      2012 Research-status Report
  • [Presentation] p53 immunostaining should be used in conjunction with p16 in differentiating metastatic cervical squamous cell carcinoma involving the lung from primary lung squamous cell carcinoma2013

    • Author(s)
      Maeda D, Inoue T, Morita S, Fukayama M.
    • Organizer
      The 102th USCAP annual meeting
    • Place of Presentation
      Baltimore, U.S.A.
    • Related Report
      2012 Research-status Report
  • [Presentation] Utility of claudin-18 immunohistochemistry for detecting benign endocervical glandular lesions exhibiting gastric differentiation (so-called lobular endocervical glandular hyperplasia)

    • Author(s)
      Daichi Maeda, Yoshiki Mikami and Masashi Fukayama.
    • Organizer
      The 103rd USCAP annual meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Related Report
      2013 Annual Research Report
  • [Book] 「卵黄嚢腫瘍」 腫瘍病理鑑別アトラス 卵巣腫瘍2012

    • Author(s)
      前田大地
    • Total Pages
      14
    • Publisher
      文光堂
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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