Role of microRNA in cystic fluid of ovarian clear cell adenocarcinoma

• Project/Area Number: 24790349
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: The University of Tokyo
• Principal Investigator: MAEDA Daichi 東京大学, 医学部附属病院, 助教 (30585500)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 卵巣明細胞腺癌 / 嚢胞内容液 / マイクロRNA / 卵巣 / 国際情報交換

Research Abstract

We succeeded in evaluating microRNAs in the cystic fluid of ovarian neoplasm. miR-21 and miR-141 were more abundant in the cystic fluid of ovarian clear cell adenocarcinoma in comparison with their precursor lesion, endometriotic cyst. This finding suggests that miR-21 and miR-141 may play a significant role in the tumorigenesis of ovarian clear cell adenocarcinoma. Furthermore, they may be useful diagnostic markers.

Research Products

• [Journal Article] Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynecologic malignancies (2014)
  • Author(s): Wu RC, Ayhan A, Maeda D, Kim KR, Clarke BA, Shaw P, Herman Chui M, Rosen B, Shih IM, Wang TL
  • Journal Title: J Pathol Volume: 232(4) Pages: 473-81
• [Journal Article] Pathogenesis of the Endometriosis-Related Ovarian Neoplasms (2014)
  • Author(s): Maeda D
  • Journal Title: Curr Obstet Gynecol Rep Volume: 3 Pages: 1-8
• [Journal Article] Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy. (2014)
  • Author(s): Wu RC, Ayhan A, Maeda D, Kim KR, Clarke BA, Shaw P, Chui MH, Rosen B, Shih IeM, Wang TL.
  • Journal Title: J Pathol. Volume: 232(4) Issue: 4 Pages: 473-81
  • DOI: 10.1002/path.4315
  • Peer Reviewed
• [Journal Article] Pathogenesis of the Endometriosis-Related Ovarian Neoplasms (2014)
  • Author(s): Maeda D.
  • Journal Title: Curr Obstet Gynecol Rep. Volume: 3 Issue: 1 Pages: 1-8
  • DOI: 10.1007/s13669-013-0073-4
• [Journal Article] Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary (2013)
  • Author(s): Koso T, Matsusaka K, Tanaka M, Arimoto T, Oda K, Kawana K, Yano T, Fujii T, Fukayama M, Halimi SA, Maeda D, Shinozaki-Ushiku A
  • Journal Title: Histopathology Volume: 63(4) Pages: 534-44
• [Journal Article] Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary. (2013)
  • Author(s): Halimi SA, Maeda D, Shinozaki-Ushiku A, Koso T, Matsusaka K, Tanaka M, Arimoto T, Oda K, Kawana K, Yano T, Fujii T, Fukayama M
  • Journal Title: Histopathology Volume: 63 Issue: 4 Pages: 534-544
  • DOI: 10.1111/his.12182
  • Peer Reviewed
• [Journal Article] Maeda D, Shih IeM. (2013)
  • Author(s): Pathogenesis and the role of ARID1A mutation in endometriosis-related ovarian neoplasms.
  • Journal Title: Adv Anat Pathol. Volume: 20(1) Issue: 1 Pages: 45-52
  • DOI: 10.1097/pap.0b013e31827bc24d
• [Presentation] Utility of claudin-18 immunohistochemistry for detecting benign endocervical glandular lesions exhibiting gastric differentiation (so-called lobular endocervical glandular hyperplasia) (2014)
  • Author(s): Maeda D, Mikami Y and Fukayama M
  • Organizer: The 103rd USCAP annual meeting
  • Place of Presentation: San Diego, USA[Poster presentation]
  • Year and Date: 2014-03-05
• [Presentation] (2013)
  • Author(s): Maeda D and Fukayama M
  • Organizer: The 17th Taiwan-Japan-Korea Joint Meeting for Gynecological Pathology,Slide conference, Session 2, J-2
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2013-10-17
• [Presentation] A case of endocervical adenocarcinoma in association with benign gastric-type glandular proliferation (2013)
  • Author(s): Maeda D and Fukayama M
  • Organizer: The 8^<th > Asia Pacific IAP congress, Slide seminar A solid and cystic ovarian mass in 33-year-old female
  • Place of Presentation: Busan, Korea
• [Presentation] 現行WHO 分類（第3 版：2003 年）の枠組みと問題点 (2013)
  • Author(s): 前田大地
  • Organizer: 第54回婦人科腫瘍学会 教育シンポジウム1：卵巣腫瘍の病理
  • Place of Presentation: 東京 ホテル グランパシフィック LE DAIBA
  • Invited
• [Presentation] Claudin-18 and MUC5AC Immunohistochemistry Is Useful for Distinction between Primary Ovarian Mucinous Adenocarcinoma and Metastatic Colorectal Carcinoma Involving the Ovary (2013)
  • Author(s): Halimi SA, Maeda D, Fukayama M.
  • Organizer: The 102th USCAP annual meeting
  • Place of Presentation: Baltimore, U.S.A.
• [Presentation] p53 immunostaining should be used in conjunction with p16 in differentiating metastatic cervical squamous cell carcinoma involving the lung from primary lung squamous cell carcinoma (2013)
  • Author(s): Maeda D, Inoue T, Morita S, Fukayama M.
  • Organizer: The 102th USCAP annual meeting
  • Place of Presentation: Baltimore, U.S.A.
• [Presentation] Utility of claudin-18 immunohistochemistry for detecting benign endocervical glandular lesions exhibiting gastric differentiation (so-called lobular endocervical glandular hyperplasia)
  • Author(s): Daichi Maeda, Yoshiki Mikami and Masashi Fukayama.
  • Organizer: The 103rd USCAP annual meeting
  • Place of Presentation: San Diego, U.S.A.
• [Book] 「卵黄嚢腫瘍」 腫瘍病理鑑別アトラス 卵巣腫瘍 (2012)
  • Author(s): 前田大地
  • Total Pages: 14
  • Publisher: 文光堂