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Re-classification for therapeutic application in SMARCB1/INI1 deficient tumors

Research Project

Project/Area Number 24790352
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionKyushu University

Principal Investigator

KOHASHI Kenichi  九州大学, 大学病院, 講師 (10529879)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords悪性ラブドイド腫瘍 / 類上皮肉腫 / SMARCB1/INI1 / Akt-mTOR / Akt-mTOR経路
Research Abstract

Pediatric SMARCB1/INI1 (INI1)-deficient tumors were able to be re-classified into the three groups: conventional type, atypical teratoid/rhabdoid (AT/R) type and small cell type. Activation in Akt-mTOR pathway was found more frequently in AT/R and small cell types than in conventional type. Meanwhile, in most cases of epithelioid sarcoma (ES) including both conventional and proximal types, the Akt-mTOR pathway was activated.
It is suggested that mTOR inhibition is a potential treatment option for AT/R and small cell types of pediatric INI1-deficient tumor and ES. ES and malignant rhabdoid tumor are suggested to be distinct tumor entities.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2014 2013 2012 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 2 results) Presentation (9 results) (of which Invited: 2 results)

  • [Journal Article] Differential microRNA expression profiles between malignant rhabdoid tumor and epithelioid sarcoma: miR193a-5p is suggested to downregulate SMARCB1 mRNA expression.2014

    • Author(s)
      Kohashi K, Yamamoto H, Kumagai R, Yamada Y, Hotokebuchi Y, Taguchi T, Iwamoto Y, Oda Y.
    • Journal Title

      Mod Pathol

      Volume: 未定 Issue: 6 Pages: 832-839

    • DOI

      10.1038/modpathol.2013.213

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of the Akt-mTOR pathway and receptor tyrosine kinase in patients with solitary fibrous tumors.2014

    • Author(s)
      Yamada Y, Kohashi K, Fushimi F, Takahashi Y, Setsu N, Endo M, Yamamoto H, Tokunaga S, Iwamoto Y, Oda Y.
    • Journal Title

      Cancer

      Volume: 未定 Issue: 6 Pages: 864-876

    • DOI

      10.1002/cncr.28506

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impact of the activation status of the Akt/mTOR pathway in synovial sarcoma.2013

    • Author(s)
      Setsu N, Kohashi K, Fushimi F, Endo M, Yamamoto H, Takahashi Y, Yamada Y, Ishii T, Yokoyama K, Iwamoto Y, Oda Y.
    • Journal Title

      Cancer

      Volume: 119 Issue: 19 Pages: 3504-3513

    • DOI

      10.1002/cncr.28255

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fascin-1 overexpression and miR-133b down-regulation in the progression of gastrointestinal stromal tumor.2013

    • Author(s)
      Yamamoto H
    • Journal Title

      Modern Pathology

      Volume: 26 Issue: 4 Pages: 563-571

    • DOI

      10.1038/modpathol.2012.198

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of AKT/i・iTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NFl-related and sporadic malignant peripheral nerve sheath tumors2013

    • Author(s)
      Makoto Endo, et a1.
    • Journal Title

      Clinical Cancer Research

      Volume: 19 Issue: 2 Pages: 450-461

    • DOI

      10.1158/1078-0432.ccr-12-1067

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutual regulation between Raf/MEK/ERK signaling and Y-box-binding protein-1 promotes prostate cancer progression2013

    • Author(s)
      Imada, K, Shiota, M., Kohashi, K., Kuroiwa, K., Song, Y., Sugimoto, M., Naito, S., Oda, Y.
    • Journal Title

      Clin. Cancer Res.

      Volume: 19(17) Issue: 17 Pages: 4638-4650

    • DOI

      10.1158/1078-0432.ccr-12-3705

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] An augmented reality navigation system for pediatric oncologic surgery based on preoperative CT and MRI images.2013

    • Author(s)
      Souzaki R, Ieiri S, Uemura M, Ohuchida K, Tomikawa M, Kinoshita Y, Koga Y, Suminoe A, Kohashi K, Oda Y, Hara T, Hashizume M, Taguchi T.
    • Journal Title

      J Pediatr Surg.

      Volume: 48 Issue: 12 Pages: 2479-83

    • DOI

      10.1016/j.jpedsurg.2013.08.025

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glypican 3 expression in tumors with loss of SMARCB1/INI1 protein expression.2013

    • Author(s)
      Kohashi K
    • Journal Title

      Human Pathology

      Volume: 44 Issue: 4 Pages: 526-533

    • DOI

      10.1016/j.humpath.2012.06.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas2012

    • Author(s)
      Setsu N, Yamamoto H, Kohashi K, Endo M, Matsuda S, Yokoyama R, Nishiyama K, Iwamoto Y, Dobashi Y, Oda Y
    • Journal Title

      Cancer

      Volume: 118(6) Issue: 6 Pages: 1637-48

    • DOI

      10.1002/cncr.26448

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibin alpha and synaptophysin immunoreactivity in synovial sarcoma with granular cell features.2012

    • Author(s)
      Setsu N
    • Journal Title

      Human Pathology

      Volume: 43 Issue: 6 Pages: 850-854

    • DOI

      10.1016/j.humpath.2011.07.012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical intervention strategies for pediatric ovarian tumors : experience with 60 cases at one institution2012

    • Author(s)
      Tajiri T, Souzaki R, Kinoshita Y, Yosue R, Kohashi K, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 28(1) Pages: 27-31

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia2012

    • Author(s)
      Matsuura T, Kohashi K, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 28(12) Pages: 1171-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical strategies for unresectable hepatoblastomas2012

    • Author(s)
      Tajiri T, Kimura O, Fumino S, Furukawa T, Iehara T, Souzaki R, Kinoshita Y, Koga Y, Suminoe A, Hara T, Kohashi K, et al
    • Journal Title

      J Pediatr Surg

      Volume: 47(12) Issue: 12 Pages: 2194-8

    • DOI

      10.1016/j.jpedsurg.2012.09.007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prognostic significance of blastemal predominant histology in initially resected Wilms' tumors : A report from the Study Group for Pediatric Solid Tumors in the Kyushu Area, Japan2012

    • Author(s)
      Kinoshita Y, Suminoe A, Inada H, Yagi M, Yanai F, Zaizen Y, Nishi M, Inomata Y, Kawakami K, Matsufuji H, Suenobu S, Handa N, Kohashi K, et al
    • Journal Title

      J Pediatr Surg

      Volume: 47(12) Issue: 12 Pages: 2205-9

    • DOI

      10.1016/j.jpedsurg.2012.09.010

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 小児軟部腫瘍2013

    • Author(s)
      孝橋賢一、山元英崇、山田裕一、小田義直
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2013-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 類上皮肉腫におけるAkt/mTOR経路関連蛋白の発現検討2013

    • Author(s)
      孝橋賢一、髙橋祐介、山田裕一、石井武彰、井浦国生、前川啓、山元英崇、岩本幸英、小田義直
    • Organizer
      第46回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-07-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 小児軟部腫瘍のゲノミクス2013

    • Author(s)
      孝橋賢一、山元英崇、山田裕一、小田義直
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Art-mTOR pathway Activation Analysis in Re-Classified Prediatric2013

    • Author(s)
      Kohashi K, Endo M, Setsu N, Takahashi Y, Yamada Y, Yamamoto H, Oda Y
    • Organizer
      SMARCB1/INI1-Dedicient Tumor 2013 Annual Meeting of USCAP
    • Place of Presentation
      Baltimore, Maryland
    • Year and Date
      2013-03-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Akt-mTOR Pathway Activation Analysis in Re-Classified Pediatric SMARCB1/INI1-Deficient Tumor2013

    • Author(s)
      Kohashi K, Endo M, Setsu N, Takahashi Y, Yamada Y, Yamamoto H, Oda Y
    • Organizer
      102nd USCAP Annual Meeting
    • Place of Presentation
      Baltimore, MD, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Re-classification of pediatric SMARCB1/INI1-deficient tumor, according to microRNA and immunohistochemical expression2012

    • Author(s)
      Kohashi K, Kishimoto H, Tanaka Y, Yamada Y, Yamamoto H, Taguchi T, Oda Y
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] microRNAと形質発現に基づいた小児SMARCB1/INI1欠失腫瘍群の再分類2012

    • Author(s)
      孝橋賢一、岸本宏志、田中祐吉、山田裕一、山元英崇、田口智章、小田義直
    • Organizer
      第71回 日本癌学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児軟部腫瘍のゲノミクス.

    • Author(s)
      孝橋賢一、山元英崇、山田裕一、小田義直
    • Organizer
      第102回日本病理学会総会.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小児軟部腫瘍

    • Author(s)
      孝橋賢一、山元英崇、山田裕一、小田義直
    • Organizer
      第55回日本小児血液・がん学会学術集会.
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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