The role of ADAMTS-13 and von Willebrand factor in venous thromboembolism.
Project/Area Number |
24790354
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | University of Miyazaki |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 血栓症 / 静脈血栓 |
Research Abstract |
Venous thromboembolism is a severe circulatory disorder that develops by occlusion of the pulmonary artery via deep venous thrombosis. The efficacy of anti-platelet agents is shown in the prevention of venous thromboembolism in some clinical studies. However, involvement of platelet and venous thrombosis is not clear. The present study investigates the von Willebrand factor (VWF), which is important to functional expression of platelet, and their control protein. Immunohistochemical study of deep venous thrombosis shows that venous thrombi is positive for fibrin, platelet, VWF and Factor VIII. Anti-FVIII antibody (Neutralizing antibody) reduced the platelet aggregation on flow chamber system, but not Anti-VWF antibody or Anti-ADAMTS-13.In rabbit venous thrombosis model, FVIII promoted the venous thrombus size, and increased the positive area of the platelet and fibrin.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage2014
Author(s)
Atsushi Yamashita, Yan Zhao, Yunosuke Matsuura, Kazuaki Yamasaki, Sayaka Moriguchi-Goto, Chihiro Sugita, Takashi Iwakiri, Nozomi Okuyama, Chihiro Koshimoto, Keiichi Kawai, Nagara Tamaki, Songji Zhao, Yuji Kuge, Yujiro Asada
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Journal Title
PLos One
Volume: 9
Issue: 1
Pages: e86426-e86426
DOI
Related Report
Peer Reviewed / Open Access
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