Proteomic analysis of human bile from chronic cholecystitis and gallbladder cancer

• Project/Area Number: 24790359
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kitasato University
• Principal Investigator: YANAGISAWA Nobuyuki 北里大学, 医学部, 講師 (80337914)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 慢性胆嚢炎 / プロテオーム / 胆嚢発癌 / 胆嚢癌

Research Abstract

The bile and tissue samples including 160 cases of chronic cholecystitis, 33 cases of bile duct carcinomas, 7 cases of gallbladder carcinomas, 2 cases of pancreaticobiliary malformations and 4 cases of gallbladder adenomas were collected. Using LC-MS analysis, 8 proteins were detected only in gallbladder cancer, and 11 proteins were not detected in gallbladder cancer.