A combination of nuclear beta-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours.

• Project/Area Number: 24790361
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kitasato University
• Principal Investigator: HIROYUKI Takahashi 北里大学, 医学部, 講師 (60377330)
• Research Collaborator: SAEGUSA Makoto
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: β-カテニン / 胃良悪性境界病変 / 病理組織診断 / β‐カテニン / 胃腺癌 / 胃腺腫

Outline of Final Research Achievements

Although recent advances in endoscopic technology, including submucosal dissection (ESD), contribute to significant improvement in detection and treatment for early gastric carcinomas (GCas), discrepant diagnosis between forceps biopsied and ESD sections sometimes occurs. Here, we focused on histological markers for accurate diagnosis of gastric tumours in forceps biopsied samples before ESD treatment.
In conclusion, the present study provided evidence that a combination of nuclear β-catenin and atypical scores which were evaluated according to degree of nuclear pseudostratification and number of branching features which were evaluated by nuclear and structural abnormalities may be useful for differential diagnosis of borderline malignancy of gastric tumours, even in forceps biopsied samples before ESD treatment.

Research Products

• [Journal Article] A combination of nuclear β-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours. (2014)
  • Author(s): Takahashi H, Ohkuma T, Tsuruta T, Saegusa M.
  • Journal Title: Histopathology Volume: 65 Issue: 6 Pages: 828-838
  • DOI: 10.1111/his.12513
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus. (2014)
  • Author(s): Takahashi, H., Yoshida, T., Matsumoto, T., Kameda, Y., Takano, Y., Tazo, Y., Inoue, H, Saegusa, M.
  • Journal Title: Hum Pathol Volume: 45 Issue: 1 Pages: 33-40
  • DOI: 10.1016/j.humpath.2013.06.020
  • Peer Reviewed / Open Access
• [Presentation] 子宮ポリープ状異型腺筋腫におけるβ-カテニン遺伝子異常の意義 (2013)
  • Author(s): 高橋博之、梶田咲美乃、鶴田智子、 橋村美紀、 亀田陽一、高野康雄、三枝 信
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 北海道札幌市
• [Presentation] β-カテニンによる胃良悪性境界病変の新規病理組織診断ツールの確立
  • Author(s): 高橋博之、大熊拓也、三枝 信
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島県広島市