Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: pathophysiological analysis in autopsy cases

• Project/Area Number: 24790364
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Toho University
• Principal Investigator: OKUBO Yoichiro 東邦大学, 医学部, 講師 (40516267)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: PTTM / 胃癌 / 肺腫瘍塞栓症 / 肺動脈 / 肺高血圧 / フィブリン血栓 / 内膜肥厚 / 腫瘍塞栓 / ＰＴＴＭ / 血行動態

Research Abstract

Pulmonary tumor thrombotic microangiopathy (PTTM) has been known as a rare and serious cancer-related pulmonary complication. However, the pathogenesis and pathophysiology of this debilitating condition still remains obscure and no effective management was recommended. The study aims to elucidate the pathophysiology of PTTM.
As a result, we found carcinoma cells in the lumen of pulmonary artery in one-third (30.4%) of autopsy with gastric carcinoma, but implantation and proliferation may be essential to induce intimal thickening that causes an increasing of pulmonary arterial pressure, because our study revealed a significant positive association between the rate of pulmonary arterial stenosis and right ventricular thickness. In addition, diffuse type gastric carcinoma may be apt to cause the remodeling of the pulmonary artery and subsequent increasing in pressure of pulmonary artery.
These findings can provide helpful information about the diagnosis and treatment of PTTM.

Research Products

• [Journal Article] Remodeling of the pulmonary artery induced by metastatic gastric carcinoma: a histopathological analysis of 51 autopsy cases. BMC Cancer (2014)
  • Author(s): Ishiwatari T, Okubo Y, Tochigi N, Wakayama M, Nemoto T, Kobayashi J, Shinozaki M, Aki K, Sasai D, Yamamoto Y, Nakayama H, Shibuya K
  • Journal Title: BMC Cancer Volume: 14 Issue: 1 Pages: 14-14
  • DOI: 10.1186/1471-2407-14-14
  • Peer Reviewed
• [Journal Article] Histopathological Imolications of Aspergillus Infection in Lung (2013)
  • Author(s): Tochigi N, Okubo Y, Ando T, Wakayama M, Shinozaki M, Gocho K, Hata Y, Ishiwatari T, Nemoto T, Shibuya K
  • Journal Title: Mediators of Inflammation Volume: 2013 Pages: 809798-809798
  • DOI: 10.1155/2013/809798
  • Peer Reviewed
• [Journal Article] How histopathology can contribute to an understanding of defense mechanisms against cryptococci. (2013)
  • Author(s): Okubo Y, Tochigi N, Wakayama M, Shinozaki M, Nakayama H, Ishiwatari T, Shimodaira K, Nemoto T, Ohno H, Kaneko Y, Makimura K, Uchida K, Miyazaki Y, Yamaguchi H, Shibuya K
  • Journal Title: Mediators of Inflammation Volume: 2013 Pages: 465319-465319
  • DOI: 10.1155/2013/465319
  • Peer Reviewed
• [Journal Article] Pathophysiological implication of reversed CT halo sign in invasive pulmonary mucormycosis: a rare case report (2013)
  • Author(s): Okubo Y, Ishiwatari T, Izumi H, Sato F, Aki K, Sasai D, Ando T, Shinozaki M, Natori K, Tochigi N, Wakayama M, Hata Y, Nakayama H, Nemoto T, Shibuya K
  • Journal Title: Diagnostic Pathology Volume: 8 Issue: 1 Pages: 82-82
  • DOI: 10.1186/1746-1596-8-82
  • Peer Reviewed
• [Journal Article] Histopathological evaluation of the efficacy of antifungals for experimental Trichosporon bloodstream infection (2013)
  • Author(s): Sasai D, Okubo Y, Ishiwatari T, Sugita T, Kaneko T, Murayama SY, Shimamura T, Shinozaki M, Hasegawa C, Mitsuda A, Tochigi N, Wakayama M, Nemoto T, Shibuya K
  • Journal Title: Jpn J Infect Dis Volume: 66 Pages: 133-139
  • Peer Reviewed
• [Journal Article] Development of a peptide nucleic acid probe to Trichosporon species and identification of trichosporonosis by use of in situ hybridization in formalin-fixed and paraffin-embedded (FFPE) sections (2013)
  • Author(s): Shinozaki M, Okubo Y, Sasai D, Nakayama H, Murayama SY, Ide T, Wakayama M, Ishiwatari T, Tochigi N, Nemoto T, Shibuya K
  • Journal Title: J Clin Microbiol Volume: 51 Issue: 1 Pages: 295-298
  • DOI: 10.1128/jcm.02221-12
  • Peer Reviewed
• [Journal Article] Development and evaluation of nucleic acid-based techniques for an auxiliary diagnosis of invasive fungal infections in formalin-fixed and paraffin-embedded (FFPE) tissues (2013)
  • Author(s): Shinozaki M, Okubo Y, Sasai D, Nakayama H, Ishiwatari T, Murayama S, Tochigi N, Wakayama M, Nemoto T, Shibuya K
  • Journal Title: Med Mycol J Volume: 53 Pages: 241-245
  • Peer Reviewed
• [Journal Article] Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs (2013)
  • Author(s): Shimodaira K, Okubo Y, Ochiai E, Nakayama H, Katano H, Wakayama M, Shinozaki M, Ishiwatari T, Sasai D, Tochigi N, Nemoto T, Saji T, Kamei K, Shibuya K
  • Journal Title: Respir Res Volume: 13(online journal) Issue: 1 Pages: 103-103
  • DOI: 10.1186/1465-9921-13-103
  • Peer Reviewed
• [Journal Article] Histopathological evaluation of the efficacy of antifungals for experimental Trichosporon bloodstream infection. (2013)
  • Author(s): Sasai D, Okubo Y, Ishiwatari T, Sugita T, Kaneko T, Murayama SY, Shimamura T, Shinozaki M, Hasegawa C, Mitsuda A, Tochigi N, Wakayama M, Nemoto T, Shibuya K
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 66 Pages: 133-139
  • Peer Reviewed
• [Journal Article] Development and evaluation of nucleic acid-based techniques for an auxiliary diagnosis of invasive fungal infections in formalin-fixed and paraffin-embedded (FFPE) tissues. (2013)
  • Author(s): Shinozaki M, Okubo Y, Sasai D, Nakayama H, Ishiwatari T, Murayama S, Tochigi N, Wakayama M, Nemoto T, Shibuya K
  • Journal Title: Medical Mycology Journal Volume: 53 Pages: 241-245
  • Peer Reviewed
• [Presentation] 癌細胞関連肺動脈構造改変に関する病理学的研究第 (2013)
  • Author(s): 石渡誉郎、大久保陽一郎、根本哲生、若山恵、山本慶郎、笹井大督、栃木直文、長谷川千花子、密田亜希、横瀬智之、島田英昭、五十嵐良典、渋谷和俊
  • Organizer: 102回日本病理学会総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2013-06-07
• [Presentation] 癌細胞関連肺動脈構造改変に関する病理学的研究
  • Author(s): 石渡誉郎, 大久保陽一郎, 根本哲生, 若山 恵, 山本慶郎, 笹井大督, 栃木直文, 長谷川千花子, 密田亜希, 横瀬智之, 島田英昭, 五十嵐良典, 渋谷和俊
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌（北海道札幌市）
• [Book] Applied gene histopathology : identification of Fusarium species in FFPE tissue sections by in situ hybridization. Hindawi Publishing Corporation. Methods in Molecular Biology. (2013)
  • Author(s): Okubo Y, Shinozaki M, Wakayama M, Nakayama H, Sasai D, Ishiwatari T, Nemoto T, Naobumi T, Shibuya K
• [Book] Applied gene histopathology: identification of Fusarium species in FFPE tissue sections by in situ hybridization (2013)
  • Author(s): Okubo Y, Shinozaki M, Wakayama M, Nakayama H, Sasai D, Ishiwatari T, Nemoto T, Naobumi T, Shibuya K.
  • Total Pages: 215
  • Publisher: Hindawi Publishing Corporation