| Project/Area Number |
24790364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | PTTM / 胃癌 / 肺腫瘍塞栓症 / 肺動脈 / 肺高血圧 / フィブリン血栓 / 内膜肥厚 / 腫瘍塞栓 / ＰＴＴＭ / 血行動態 |
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| Research Abstract |
Pulmonary tumor thrombotic microangiopathy (PTTM) has been known as a rare and serious cancer-related pulmonary complication. However, the pathogenesis and pathophysiology of this debilitating condition still remains obscure and no effective management was recommended. The study aims to elucidate the pathophysiology of PTTM.
As a result, we found carcinoma cells in the lumen of pulmonary artery in one-third (30.4%) of autopsy with gastric carcinoma, but implantation and proliferation may be essential to induce intimal thickening that causes an increasing of pulmonary arterial pressure, because our study revealed a significant positive association between the rate of pulmonary arterial stenosis and right ventricular thickness. In addition, diffuse type gastric carcinoma may be apt to cause the remodeling of the pulmonary artery and subsequent increasing in pressure of pulmonary artery.
These findings can provide helpful information about the diagnosis and treatment of PTTM.
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