Study of molecular pathology of salivary gland tumor

• Project/Area Number: 24790369
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: OHTOMO Rie 独立行政法人国立がん研究センター, 中央病院, 外来研究員 (50626322)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 唾液腺腫瘍 / SOX10 / 病理診断 / Sox10

Research Abstract

Salivary gland tumors are relatively rare and morphologically diverse and heterogeneous tumors; therefore, histogenesis-based tumor markers are sorely needed to aid in diagnosing and determining the cell type of origin. SOX10 protein is a transcription factor known to be crucial in the specification of the neural crest. In addition, positive expression has also been implicated in the major salivary gland. SOX10 expression clearly delineated two distinct subtypes of human salivary gland tumors. In normal human salivary gland tissue, SOX10 expression was specific to the nuclei of acini and both luminal and abluminal cells of intercalated ducts but not in other sites. Moreover, the murine model suggested that SOX10 continued to be expressed from the developmental stage to adulthood in the acinar and both luminal and abluminal intercalated ducts in the major salivary gland. Thus, SOX10 is a novel marker for diagnosing and understanding the histogenesis of salivary gland tumors.

Research Products

• [Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: A clue to the histogenesis and diagnosis (2013)
  • Author(s): Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima M, Akazawa C, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
  • Journal Title: Modern Pathology Volume: Aug;26(8): Issue: 8 Pages: 1041-50
  • DOI: 10.1038/modpathol.2013.54
  • Peer Reviewed
• [Presentation] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors (2012)
  • Author(s): 大友梨恵
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌
• [Presentation] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors. (2012)
  • Author(s): 大友梨恵
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌