| Project/Area Number |
24790376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 組織幹細胞 / 17型コラーゲン / 毛包幹細胞 / 細胞極性 / ヘミデスモソーム / aPKC / １７型コラーゲン |
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| Research Abstract |
Cell polarity plays important functional roles in differentiation and proliferation of invertebrates and mammalian stem cells, however their function and maintenance in hair follicle stem cells (HFSCs) are now unclear. COL17A1 is one of the hemidesmosomal transmembrane proteins, which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements, involved in epidermal adhesion. Previously, we showed that COL17A1 is essential for maintenance of hair follicle stem cells (Cell Stem Cell 2011). Now, we are analyzing 'How COL17A1 regulates the fate of hair follicle stem cells by focusing on cell polarity'.
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