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Functional analysis of Id2 in intestinal tumorigenesis

Research Project

Project/Area Number 24790379
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionUniversity of Fukui

Principal Investigator

BIYAJIMA Kyoko  福井大学, 医学部, 特命助教 (30552020)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsId2 / Apc / 腸管腫瘍 / Wntシグナル / Wnt
Research Abstract

To genetically examine the physiological role of increased expression of Id2 in the intestinal tumorigenesis, we crossed the Apc delta 716 mice with the Id2-/- mice, and evaluated the polyp-number, -size, and -apoptosis in the Apc delta 716;Id2-/- (Apc;Id2) mice. Notably, lack of Id2 reduced the number of ileal polyps by ~80%, as compared with that of the control mice. On the other hand, Id2 deficiency had a little effect on the proliferation and apoptosis of the adenoma epithelium of Apc delta 716 mice. These results raise the possibilities that the elevated expression of Id2 is implicated in the process of intestinal adenoma-initiation. To further analyze the mechanisms, we next conducted DNA microarray analysis. This comprehensive analysis revealed that Id2 knockout increases expression of c-Myc antagonist gene and tumor-initiation suppressor genes. These results strongly suggest that Id2 promotes ileal adenoma initiation through suppression of those genes.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2012

All Presentation (2 results)

  • [Presentation] Id2-deficiency attenuates Apc-deficient intestinal tumorigenesis Kyoko Biyajima2012

    • Author(s)
      Xiaoding Shen, Kentaro Mori, Makoto M. Taketo, Yoshifumi Yokota
    • Organizer
      第35回日本分子生物学会年回
    • Place of Presentation
      マリンメッセ福岡、ポスター発表
    • Year and Date
      2012-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Id2-deficiency attenuates Apc-deficient intestinal tumorigenesis2012

    • Author(s)
      美谷島杏子
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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