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Identification of IL-10-producing B cells to suppress multiple sclerosis and elucidation of its suppression mechanism

Research Project

Project/Area Number 24790384
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionOsaka University

Principal Investigator

MATSUMOTO Masanori  大阪大学, 免疫学フロンティア研究センター, 特任助教 (50542106)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords免疫 / plasmablasts / IL-10 / 脳脊髄炎 / 多発性硬化症 / 国際研究者交流
Research Abstract

B cells can suppress experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, by secreting the anti-inflammatory cytokine IL-10. However, which B cell subsets can serve as IL-10-producing B cells to suppress EAE remains unknown. By using IL-10 reporter mice, we found that plasmablasts in the draining lymph nodes (dLNs) predominantly expressed IL-10 during EAE. In addition, mice lacking plasmablasts developed an exacerbated EAE. Thus, these results suggest that plasmablasts in the dLNs can serve as IL-10 producers to limit EAE inflammation.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2013 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] Plasmablasts control T-cell autoimmunity through IL-10 production2013

    • Author(s)
      松本真典
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] plasmablasts control T cell autoimmunity through IL-10 production

    • Author(s)
      松本真典
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://lymph.ifrec.osaka-u.ac.jp/index_j.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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