| Project/Area Number |
24790385
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
|
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| Research Institution | University of Occupational and Environmental Health, Japan (2013)
Kobe University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | Ｗｎｔ５ａ / Ｒｏｒ２ / ＵＵＯ / ＭＭＰ－２ / 腎不全 / 腎線維化 / 基底膜破壊 / メタボローム解析 / 組織線維化 |
|---|
| Research Abstract |
Expression of receptor tyrosine kinase Ror2 is induced in the affected kidneys of UUO model mice by western blotting. Further, MMP-2, involved in disruption of basement membrane, is induced in Ror2-positive renal epithelial cells by immunofluorescence. Expectedly, disrupted basement membrane is observed in the neighborhood of Ror2-positive cells, indicating crucial role of Wnt5a-Ror2 signaling in the progression of renal malfunction.
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