Analysis of Wnt5a-Ror signaling in renal fibrosis
Project/Area Number |
24790385
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
|
Research Institution | University of Occupational and Environmental Health, Japan (2013) Kobe University (2012) |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Wnt5a / Ror2 / UUO / MMP-2 / 腎不全 / 腎線維化 / 基底膜破壊 / メタボローム解析 / 組織線維化 |
Research Abstract |
Expression of receptor tyrosine kinase Ror2 is induced in the affected kidneys of UUO model mice by western blotting. Further, MMP-2, involved in disruption of basement membrane, is induced in Ror2-positive renal epithelial cells by immunofluorescence. Expectedly, disrupted basement membrane is observed in the neighborhood of Ror2-positive cells, indicating crucial role of Wnt5a-Ror2 signaling in the progression of renal malfunction.
|
Report
(3 results)
Research Products
(6 results)
-
-
-
[Journal Article] Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis.2013
Author(s)
Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., Minami, Y.
-
Journal Title
Genes Cells
Volume: 18
Issue: 7
Pages: 608-619
DOI
Related Report
Peer Reviewed
-
-
-