| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we investigated the role of target genes of ASPL-TFE3 chimeric oncogene in the tumorigenesis and pathogenesis of alveolar soft part sarcoma. We identified p21 and a signaling molecule as direct transcriptional targets of ASPL-TFE3. Our results showed that ASPL-TFE3 induced cellular senescence and the expression of pro-inflammatory cytokines associated with the SASP by upregulating p21 expression. Furthermore, we found that ASPL-TFE3 lead to the inappropriate activation of signal transduction pathway and the promotion of cell motility by upregulating signaling molecule. These results suggest that ASPL-TFE3 contribute to pathogenesis and progression of alveolar soft part sarcoma by inducing aberrant expression of transcriptional targets implicated in cellular senescence and signal transduction mechanisms.
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