Research Project
Grant-in-Aid for Young Scientists (B)
We identified a novel disrupted in schizophrenia 1 (DISC1)-associate protein, named CAMDI. CAMDI knock-down experiment by sh-RNA using in utero electroporation revealed severely impairment of radial migration with disoriented centrosomes. The CAMDI gene knockout mice revealed an abnormal neuronal migration, short dendrite and high spine density at the cerebrum. The cerebrum is known as a brain region related to high-level brain functions such as recognition, learning and memory formation. In addition, abnormality of these functions observed in a brain of psychiatric patients. Thus, we studied a behavior analysis of the CAMDI knockout mice. As a result, the knockout mice showed a hypermobility, hypo-sociability and repetitive behavior. CAMDI gene located a 2q31.2 where is known as a candidate region for autism or related disease. These findings indicate that CAMDI have an important role for normal brain development and might be due to a psychiatric disorder.
All 2013 2012 Other
All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Remarks (1 results)
Mol. Cell
Volume: 51 (1) Pages: 20-34
Volume: 51 Issue: 1 Pages: 1-15
10.1016/j.molcel.2013.04.023
Volume: in press
http://logos.ls.toyaku.ac.jp/Life-Science/lmb-8/
