Study for relationship between CAMDI function in cortical lamination and psychiatric disorders
Project/Area Number |
24790392
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | CAMDI / 脳 / 発生 / ノックアウトマウス / DISC1 / 統合失調症 / 大脳 / 精神疾患 |
Research Abstract |
We identified a novel disrupted in schizophrenia 1 (DISC1)-associate protein, named CAMDI. CAMDI knock-down experiment by sh-RNA using in utero electroporation revealed severely impairment of radial migration with disoriented centrosomes. The CAMDI gene knockout mice revealed an abnormal neuronal migration, short dendrite and high spine density at the cerebrum. The cerebrum is known as a brain region related to high-level brain functions such as recognition, learning and memory formation. In addition, abnormality of these functions observed in a brain of psychiatric patients. Thus, we studied a behavior analysis of the CAMDI knockout mice. As a result, the knockout mice showed a hypermobility, hypo-sociability and repetitive behavior. CAMDI gene located a 2q31.2 where is known as a candidate region for autism or related disease. These findings indicate that CAMDI have an important role for normal brain development and might be due to a psychiatric disorder.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin22013
Author(s)
Sugiura A., Nagashima S., Tokuyama T., Amo T., Matsuki Y., Ishido S., Kudo Y., McBride HM., Fukuda T., Matsushita N., Inatome R., Yanagi S
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Journal Title
Mol. Cell
Volume: 51 (1)
Pages: 20-34
Related Report
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[Journal Article] MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.2013
Author(s)
Sugiura, A., Nagashima, S., Tokuyama, T., Amo, T., Matsuki, Y., Ishido, S., Kudo, Y., McBride, H.M., Fukuda, T., Matsushita, T., Inatome, R., and C Yanagi, S.
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Journal Title
Mol. Cell
Volume: 51
Issue: 1
Pages: 1-15
DOI
Related Report
Peer Reviewed
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