Spatio-temporal crosstalk between Ly49Q-mediated immune response and autophagy
| Project/Area Number |
24790396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | 独立行政法人国立国際医療研究センター |
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Principal Investigator |
TANAKA Masashi 独立行政法人国立国際医療研究センター, その他部局等, 研究員 (60381167)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 炎症 |
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| Research Abstract |
To examine the relationship between Ly49Q, an inhibitory receptor expressed on inflammatory immune cells, and autophagy pathway which plays a significant roles for homeostasis, cellular response was analyzed using inflammatory immune cells from Ly49Q-knockout mice and RAW264.7 cell lines in which Ly49Q expression was high or low. On the basis of analyses of cathepsin-maturation involving in the autophagy, cytokine expression profiles in response to inflammatory stimuli, localization changes of endosomal/lysosomal organelles after inflammatory stimuli, it was suggested that Ly49Q involves in the inhibitory pathway for autophagy and the regulation of organelle-trafficking in inflammatory immune cells.
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Report
(3 results)
Research Products
(4 results)
