| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We investigated cellular senescence and human aging-dependent glycan changes on human diploid fibroblasts derived from differently-aged skin and human cardiac cells derived from elderly patient with heart disease using lectin microarray. The glycan profiles in their early passage of elderly-derived fibroblasts were different from those of fetal-derived fibroblasts, especially α2-6sialylated glycan forms. Moreover, mesenchymal stem cell markers, such as CD-antigens including glycoproteins, in patient-cardiac cells were decreased in cellular senescence.
Therefore, it was suggested that the glycan change has the potential for senescence indicator. In the future, these findings will be helpful to evaluate the various multipotent stem cells.
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