Groundwork study for senescence indicator leading to diseases prevention and treatment with the aging
| Project/Area Number |
24790397
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
ITAKURA Yoko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30582746)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 糖鎖 / 細胞老化 / 個体老化 / 再生 / レクチンマイクロアレイ / 糖鎖プロファイル / 老化 / 幹細胞 |
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| Outline of Final Research Achievements |
We investigated cellular senescence and human aging-dependent glycan changes on human diploid fibroblasts derived from differently-aged skin and human cardiac cells derived from elderly patient with heart disease using lectin microarray. The glycan profiles in their early passage of elderly-derived fibroblasts were different from those of fetal-derived fibroblasts, especially α2-6sialylated glycan forms. Moreover, mesenchymal stem cell markers, such as CD-antigens including glycoproteins, in patient-cardiac cells were decreased in cellular senescence.
Therefore, it was suggested that the glycan change has the potential for senescence indicator. In the future, these findings will be helpful to evaluate the various multipotent stem cells.
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Report
(4 results)
Research Products
(8 results)
