| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Detailed mutational trend of a mutator malaria parasite possessing proofreading deficient DNA polymerase δ was analyzed. The mutation spectrum was biased, and the base substitution of the parasite was influenced by sequence context. By using the mutator parasite, chloroquine resistant parasites were successfully generated. DNA sequencing analysis of genes involved in genome replication and/or stability with global Plasmodium falciparum DNA samples was also conducted, and fundamental information on the genetic polymorphism was obtained.
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