| Project/Area Number |
24790404
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
|
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| Research Institution | Kagoshima University (2013)
University of the Ryukyus (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
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| Keywords | ワクチン / マラリア / 伝搬阻止ワクチン / 三日熱マラリア原虫 / 抗原の反復整列 / アジュバント / 組換えタンパク質 |
|---|
| Research Abstract |
We have developed a new technology to enhance immune responses by generating complex which composed DNA-binding protein fused vaccine antigen and DNA (DBP-Ag/DNA). In this system, DNA was used as scaffold material, not genetic information. Vaccine efficacy of the DBP-Ag/DNA complex was evaluated using an ookinete surface protein of Plasmodium vivax, Pvs25. The DBP-Ag/DNA complex immunized mice were conferred a high immune response compared to Pvs25 alone immunized group. This system may be a promising approach for development of subunit vaccines against malaria.
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