Suppression of experimental cerebral malaria by activation of nonlethal malaria parasite-specific CD4+T cells via MHC class II in mice coinfected with Plasmodium berghei ANKA and nonlethal Pb XAT
| Project/Area Number |
24790405
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Research Collaborator |
KOBAYASHI Fumie 杏林大学, 医学部, 教授 (20118889)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マラリア / 弱毒株 / 複合感染 / 病態重症化 / MHC class II / CD4+T細胞 / 比較ゲノム / 比較プロテオーム / マラリア原虫 / 遺伝子変異 / Pb ANKA / Pb XAT / T細胞受容体 |
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| Outline of Final Research Achievements |
Experimental cerebral malaria (ECM) caused by Plasmodium berghei (Pb) ANKA has been suppressed by coinfection with nonlethal Pb XAT. In this study, we showed that CD4+T cells which are activated via MHC class II play a crucial role for development of ECM in mice singly infected with Pb ANKA. The activation of CD4+T cells via MHC class II in Pb ANKA-infected mice was modulated by coinfection with Pb XAT, resulting in the suppression of ECM in mice coinfected with Pb ANKA and Pb XAT. Results from analysis using Ciita-deficient mice, which lack MHC class II expression, suggest that Pb XAT-specific CD4+T cells were induced via MHC class II in coinfected mice.
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Report
(4 results)
Research Products
(52 results)
