| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Experimental cerebral malaria (ECM) caused by Plasmodium berghei (Pb) ANKA has been suppressed by coinfection with nonlethal Pb XAT. In this study, we showed that CD4+T cells which are activated via MHC class II play a crucial role for development of ECM in mice singly infected with Pb ANKA. The activation of CD4+T cells via MHC class II in Pb ANKA-infected mice was modulated by coinfection with Pb XAT, resulting in the suppression of ECM in mice coinfected with Pb ANKA and Pb XAT. Results from analysis using Ciita-deficient mice, which lack MHC class II expression, suggest that Pb XAT-specific CD4+T cells were induced via MHC class II in coinfected mice.
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