A study on energy metabolism of fox tapeworm Echinococcus multilocularis
Project/Area Number |
24790407
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Parasitology (including Sanitary zoology)
|
Research Institution | Nihon University |
Principal Investigator |
MATSUMOTO Jun 日本大学, 生物資源科学部, 准教授 (70296169)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 寄生虫 / エキノコックス / エネルギー代謝 / メタボロミクス / グルコース / トランスポーター / 創薬 / 寄生適応 / 人獣共通寄生虫症 / メタボローム解析 / トランスクリプトーム解析 |
Research Abstract |
Echinococcus multilocularis (Em) is a zoonotic parasite, distributed widely in northern hemisphere including Japan. The larval stage of Em causes life-threatening disease in humans called alveolar echinococcosis. The present study aimed to provide an overview of energetic metabolism pathway in Em. The result of metabolomics analysis using larval Em cultured under aerobic/anaerobic condition suggests that the parasite possesses both aerobic and anaerobic metabolic pathways. The presence of the putative anaerobic pathway is consistent with our previous study (Matsumoto et al., 2008), leading us to infer that the parasite uses this unique metabolic pathway to survive in anaerobic conditions in host tissues. In addition, we obtained the complete sequence for 3 glucose transporter genes, which are supposed to be involved in energy uptake by Em. Further analyses on energy metabolism in Em are presently carried out to identify novel targets for chemotherapy of alveolar echinococcosis.
|
Report
(3 results)
Research Products
(28 results)
-
[Journal Article] Prevalence of Dirofilaria immitis among shelter dogs in Tokyo, Japan after a decade: comparison of 1999-2001 and 2009-20112014
Author(s)
Oi, M., Yoshikawa, S., Ichikawa, Y., Nakagaki, K., Matsumoto J., and Nogami, S.
-
Journal Title
Parasite
Volume: 21
Pages: 10-10
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Characterization of a surface glycoprotein from Echinococcus multilocularis and its mucosal vaccine potential in dogs2013
Author(s)
Kouguchi, H., Matsumoto, J., Nakao, R., Yamano, K., Oku, Y., and Yagi, K
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Successful resolution of esophageal granulomas in a dog infected with Spirocerca lupi2013
Author(s)
Okanishi, H., Matsumoto, J., Aoki, H., Kagawa, Y., Asano, K., Nogami, S., and Watari, T
-
Journal Title
Journal of Veterinary Medical Science
Volume: 75(12)
Pages: 1629-1632
NAID
Related Report
Peer Reviewed
-
[Journal Article] Case report : First confirmed case of canine peritoneal larval cestodiasis caused by Mesocestoides vogae (syn. M. corti) in Japan2013
Author(s)
Kashiide, T., Matsumoto, J., Yamaya, Y., Uwasawa, A., Miyoshi, A., Yamada, K., Watari, T., and Nogami, S.
-
Journal Title
Veterinary Parasitology
Volume: 201(1-2)
Pages: 154-157
Related Report
Peer Reviewed
-
-
-
[Journal Article] Characterization of a surface glycoprotein from Echinococcus multilocularis and its mucosal vaccine potential in dogs2013
Author(s)
Kouguchi, H., Matsumoto, J., Nakao, R., Yamano, K., Oku, Y., and Yagi, K.
-
Journal Title
PLoS ONE
Volume: 8
Issue: 7
Pages: e69821-e69821
DOI
Related Report
Peer Reviewed
-
[Journal Article] Successful resolution of esophageal granulomas in a dog infected with Spirocerca lupi2013
Author(s)
Okanishi, H., Matsumoto, J., Aoki, H., Kagawa, Y., Asano, K., Nogami, S., and Watari, T.
-
Journal Title
Journal of Veterinary Medical Science
Volume: 75
Pages: 1629-1632
NAID
Related Report
Peer Reviewed
-
[Journal Article] Case report: First confirmed case of canine peritoneal larval cestodiasis caused by Mesocestoides vogae (syn. M. corti) in Japan2013
Author(s)
Kashiide, T., Matsumoto, J., Yamaya, Y., Uwasawa, A., Miyoshi, A., Yamada, K., Watari, T., and Nogami, S.
-
Journal Title
Veterinary Parasitology
Volume: 201
Issue: 1-2
Pages: 154-157
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] A pilot study on developing a mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3 : vaccine efficacy and immunology2012
Author(s)
Dang Z, Yagi K, Oku Y, Kouguchi H, Kajino K, Matsumoto J, Nakao R, Wakaguri H, Toyoda A, Yin H, Sugimoto C
-
Journal Title
PLoS Neglected Tropical Diseases
Volume: 6
Issue: 3
Pages: e1570-e1570
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] Dog biting lice (Trichodectes canis) found on Japanese raccoon dogs (Nyctereutes procyonoides viverrinus) in Japan2013
Author(s)
Oi, M., Tshichiya, H., Tshichiya, T., Takizawa, M., Konno, T., Okabayashi, K., Narita, T., Matsumoto, J., Sugiya, H., Nogami, S.
Organizer
24th International Conference of the World Association for the Advancement of Veterinary Parasitology
Place of Presentation
Perth, Australia
Related Report
-
-
-
-
-
-
-
-
-
[Book] 寄生虫病学
Author(s)
松本淳(分担)
Publisher
緑書房(印刷中)
Related Report