Functional analysis of a signal transduction system in pathogenic fungi Aspergillus fumigatus
| Project/Area Number |
24790410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
HAGIWARA Daisuke 千葉大学, 真菌医学研究センター, 特任助教 (20612203)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 情報伝達系 / 二成分制御系 / ヒスチジンキナーゼ / MAPKカスケード / 浸透圧ストレス / 環境応答機構 / 情報伝達機構 / MAPK |
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| Research Abstract |
Recently, fungal infection has increased. In order to understand how the causative fungus Aspergillus fumigatus survives in a stressful environment and during infection, we focused on a stress response signaling mechanism, High Osmolar Glycerol (HOG) pathway. We constructed the gene deletion mutants of each component of the pathway, and investigated the components. We found that one histidine kinase, NikA, is involved in conidiation, hyphal morphogenesis, osmotic stress resistance, and fungicide response in A. fumigatus. These results will be useful for further understanding of the response mechanism against extracellular stresses and also for development of new drugs targeting this signaling pathway in A. fumigatus.
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Report
(3 results)
Research Products
(17 results)
