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Functional analysis of a signal transduction system in pathogenic fungi Aspergillus fumigatus

Research Project

Project/Area Number 24790410
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including Mycology)
Research InstitutionChiba University

Principal Investigator

HAGIWARA Daisuke  千葉大学, 真菌医学研究センター, 特任助教 (20612203)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords情報伝達系 / 二成分制御系 / ヒスチジンキナーゼ / MAPKカスケード / 浸透圧ストレス / 環境応答機構 / 情報伝達機構 / MAPK
Research Abstract

Recently, fungal infection has increased. In order to understand how the causative fungus Aspergillus fumigatus survives in a stressful environment and during infection, we focused on a stress response signaling mechanism, High Osmolar Glycerol (HOG) pathway. We constructed the gene deletion mutants of each component of the pathway, and investigated the components. We found that one histidine kinase, NikA, is involved in conidiation, hyphal morphogenesis, osmotic stress resistance, and fungicide response in A. fumigatus. These results will be useful for further understanding of the response mechanism against extracellular stresses and also for development of new drugs targeting this signaling pathway in A. fumigatus.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (16 results) (of which Invited: 1 results)

  • [Journal Article] NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus2013

    • Author(s)
      Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, Kamei K, Gonoi T, Kawamoto S.
    • Journal Title

      Plos ONE

      Volume: 8 Issue: 12 Pages: 1-15

    • DOI

      10.1371/journal.pone.0080881

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] The role of AtfA in conidia stress tolerance and its regulatory pathway in pathogenic fungus Aspergillus fumigatus2014

    • Author(s)
      Hagiwara D, Suzuki S, Kamei K, Gonoi T, Kawamoto S
    • Organizer
      12^<th> European Conference on Fungal Genetics
    • Place of Presentation
      Seville, Spain
    • Year and Date
      2014-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of cultivation temperature on characteristics of conidia in pathogenic fungus Aspergillus fumigatus2014

    • Author(s)
      Hagiwara D, Suzuki S, Kamei K, Gonoi T, Kawamoto S
    • Organizer
      11^<th> Asperfest
    • Place of Presentation
      Seville, Spain
    • Year and Date
      2014-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel transcriptional regulator AtrR of Aspergillus fumigatus is required for azole resistance, hypoxia growth, and expression of ABC transporter gene cdr1B2014

    • Author(s)
      Hagiwara D, Shimizu K, Ohba A, Kamei K, Gonoi T, Kawamoto S
    • Organizer
      6^<th> Advances Against Aspergillosis
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2014-02-26
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel transcriptional regulator AtrR of Aspergillus fumigatus is required for azole resistance, hypoxia growth, and expression of ABC transporter gene cdr1B2014

    • Author(s)
      Hagiwara D., K. Shimizu, A. Ohba, K. Kamei, T. Gonoi, S. Kawamoto, K. Gomi
    • Organizer
      6th Advances Against Aspergillosis
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effects of cultivation temperature on characteristics of conidia in pathogenic fungus Aspergillus fumigatus2014

    • Author(s)
      Hagiwara D., S. Suzuki, K. Kamei, T. Gonoi, S. Kawamoto
    • Organizer
      11th Asperfest
    • Place of Presentation
      Seville, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] The role of AtfA in conidia stress tolerance and its regulatory pathway in pathogenic fungus Aspergillus fumigatus2014

    • Author(s)
      Hagiwara D., S. Suzuki, K. Kamei, T. Gonoi, S. Kawamoto
    • Organizer
      12th European Conference on Fungal Genetics
    • Place of Presentation
      Seville, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] 病原真菌Aspergillus fumigatusのアゾール剤耐性におけるAtrRの多様な機能2013

    • Author(s)
      萩原大祐、大場歩、清水公徳、川本進、五味勝也
    • Organizer
      第13回糸状菌分子生物学コンファレンス
    • Place of Presentation
      つくば
    • Year and Date
      2013-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] カビ胞子のストレス耐性機構の解明をめざして、糸状菌分子生物学研究会若手の会2013

    • Author(s)
      萩原大祐
    • Organizer
      第一回ワークショップ
    • Place of Presentation
      つくば
    • Year and Date
      2013-11-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 病原真菌Aspergillus fumigatusの胞子におけるストレス耐性機構の解析2013

    • Author(s)
      萩原大祐、五ノ井透、川本進
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-26
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Repression of the phosphor-transmitter gene ypdA resulting in growth defect in Aspergillus fumigatus2013

    • Author(s)
      Hagiwara D, Takahashi H, Nakayama M, Abe K, Gonoi T, Kawamoto S
    • Organizer
      27^<th> Fungal Genetics Conference
    • Place of Presentation
      CA USA
    • Year and Date
      2013-03-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 病原真菌Aspergillus fumigatusの胞子におけるストレス耐性機構の解析2013

    • Author(s)
      萩原大祐、五ノ井透、川本進
    • Organizer
      第7回に本ゲノム微生物学会年会
    • Place of Presentation
      長浜
    • Year and Date
      2013-03-09
    • Related Report
      2013 Final Research Report
  • [Presentation] カビ胞子のストレス耐性機構の解明をめざして2013

    • Author(s)
      萩原大祐
    • Organizer
      糸状菌分子生物研究会若手の会 第一回 ワークショップ
    • Place of Presentation
      つくば市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 病原真菌Aspergillus fumigatusのアゾール剤耐性におけるAtrRの多様な機能2013

    • Author(s)
      萩原大祐、大場歩、清水公徳、川本進、五味勝也
    • Organizer
      第13回糸状菌分子生物学コンファレンス
    • Place of Presentation
      つくば市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 病原真菌Aspergillus fumigatusの胞子におけるストレス耐性機構の解析2013

    • Author(s)
      萩原大祐
    • Organizer
      第7回日本ゲノム微生物学会年会
    • Place of Presentation
      長浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Repression of the phosphor-transmitter gene ypdA resulting in growth defect in Aspergillus fumigatus2013

    • Author(s)
      萩原大祐
    • Organizer
      27th Fungal Genetics Conference
    • Place of Presentation
      Pacific Grove, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Aspergillus fumigatusの多様なストレスおよび薬剤に対する浸透圧応答経路の機能解析2012

    • Author(s)
      萩原大祐、豊留孝仁、高橋梓、亀井克彦、五ノ井透、川本進
    • Organizer
      第56回日本医真菌学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-11
    • Related Report
      2013 Final Research Report 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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