| Project/Area Number |
24790414
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
OKADA KAZUHISA 大阪大学, 微生物病研究所, 特任助教 (40420434)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Vibrio cholerae / コレラ菌 / タイ / コレラ |
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| Research Abstract |
In this study, we found three isolates TSY216, TSY241, and TSY421, of Vibrio cholerae O1 carrying a 0.9 Mb replicon (Ch3) in addition to the two circular chromosomes, 1 (Ch1; 3.0 Mb) and 2 (Ch2; 1.0 Mb). The genome of TSY216 carrying the Ch3 was compared with that of epidemic V. cholerae O1. The chromosomes 1 and 2 were very similar among TSY216 and other epidemic strains. However, the Ch3 did not share any conserved region with Ch1 and Ch2. Ch3 was found to encode 1,031 ORFs and 66 genes encoding tRNAs for 20 amino acids. The origin and function of Ch3 remain unidentifiable. The acquisition of a large-scale gene set of the third replicon may provide an opportunity to result in a new emerging form of V. cholerae O1.
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