| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Streptococcus pneumoniae is a major etiologic agent of otitis media, pneumonia, sepsis, and meningitis. It is rare that the organism causes fulminant infections.
During 1998 to 2013, a total of 22 sporadic fulminant pneumococcal infections were reported to us. In order to reveal the mechanism by which S. pneumoniae causes fulminant disease, pathogenicity of the bacteria was investigated. S. pneumoniae strains isolated from fulminant infections and other type of disease, which showed same serotypes and sequence types, were used to compare pathogenicity in vitro. Survival in human peripheral blood neutrophil, stimulation of platelet activation, effect on the induction of cytokine (IL-6, IL-8, IL-1 beta) of macrophage cell line THP-1 were investigated. But no signification difference between S. pneumoniae isolated from various types could be found. All of these results showed the possibility that the host factor(s) may be important for occurrence of overwhelming pneumococcal infection.
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