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Analysis of aminoglycoside-resistant genes in highly multidrug-resistant Pseudomonas aeruginosa

Research Project

Project/Area Number 24790432
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including Mycology)
Research Institution独立行政法人国立国際医療研究センター

Principal Investigator

TADA Tatsuya  独立行政法人国立国際医療研究センター, その他部局等, その他 (00624644)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords多剤耐性緑膿菌 / 分子疫学 / 薬剤耐性因子 / アミノグリコシド / β-ラクタマーゼ / アミノグリコシド耐性
Research Abstract

We performed a molecular epidemiolygical study of 300 clinical isolates of Pseudomonas aeruginosa in 2011 in Japan. Of them, we found a novel aminoglycoside 6'-N-acetyltransferase gene, aac(6')-Iaj.The encoded protein, AAC(6')-Iaj, was found to consist of 184 amino acids, with 70% identity to AAC(6')-Ia. Escherichia coli transformed with a plasmid containing the aac(6')-Iaj gene acquired resistance to all aminoglycosides tested except gentamicin. Of note, aac(6')-Iaj contributed to the resistance to arbekacin.
In 2012, we found two novel IMP-type metallo-beta-lactamase variants, IMP-43 and IMP-44, which were identified in multidrug-resistant Pseudomonas aeruginosa isolates obtained in medical settings in Japan. These two variants had more efficient catalytic activities against all carbapenems tested, including dripenem, imipenem, meropenem and panipenem.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 12 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Biochemical analysis of metallo-β-lactamase NDM-3 from a multidrug-resistant Escherichia coli strain isolated in Japan2014

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Pages: 3538-3540

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dissemination of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and emergence of OXA-72 carbapenemase coproducers in Japan2014

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Masahiro Shimojima, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Pages: 2916-2920

    • Related Report
      2013 Final Research Report
  • [Journal Article] NDM-1 metalloβ-lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal2014

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Rajan K. Dahal, Manoj K. Sah, Hiroshi Ohara, Kayo Shimada, Teruo Kirikae, Bharat M. Pokhrel
    • Journal Title

      BMC Infect Dis

      Volume: 14 Pages: 56-56

    • Related Report
      2013 Final Research Report
  • [Journal Article] Biochemical analysis of the metallo-β-lactamase NDM-3 from a multidrug-resistant Escherichia coli strain isolated in Japan.2014

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Shimada K, Kirikae T.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Pages: 3538-3540

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissemination of 16S rRNA Methylase ArmA-Producing Acinetobacter baumannii and Emergence of OXA-72 Carbapenemase Coproducers in Japan.2014

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Issue: 5 Pages: 2916-2920

    • DOI

      10.1128/aac.01212-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NDM-1 Metallo-β-Lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal.2014

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Dahal RK, Sah MK, Ohara H, Shimada K, Kirikae T, Pokhrel BM.
    • Journal Title

      BMC Infect Dis

      Volume: 14 Issue: 1 Pages: 56-56

    • DOI

      10.1186/1471-2334-14-56

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissemination of multidrug-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (NDM-1 and OXA-72) and 16S rRNA methylases (ArmA, RmtC and RmtF) in Nepal2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Rajan K. Dahal, Shyam K. Mishra, Hiroshi Ohara, Kayo Shimada, Teruo Kirikae, Bharat Pokhrel
    • Journal Title

      Int J Antimicrob Agents

      Volume: 42 Pages: 372-374

    • Related Report
      2013 Final Research Report
  • [Journal Article] IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase acrivities in multidrug-resistant Pseudomonas aeruginosa2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Masahiro Shimojima, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Pages: 4427-4432

    • Related Report
      2013 Final Research Report
  • [Journal Article] Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in Vietnam2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Yasuyuki Kato, Norio Ohmagari, Nozomi Takeshita, Nguyen V. Hung, Doan M. Phuong, Truong A. Thu, Nguyen G. Binh, Nguyen Q. Anh, Tran T. T. Nga, Pham H. Truong, Phan T. Xuan, Le T. A. Thu, Nguyen T. Son, Teruo Kirikae
    • Journal Title

      BMC Infect Dis

      Volume: 13 Pages: 251-251

    • Related Report
      2013 Final Research Report
  • [Journal Article] NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Rajan K. Dahal, Manoj K. Sah, Hiroshi Ohara, Teruo Kirikae, Bharat M. Pokhrel
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Pages: 2394-2396

    • Related Report
      2013 Final Research Report
  • [Journal Article] Novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Masahiro Shimojima, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Pages: 96-100

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dissemination of multidrug-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (NDM-1 and OXA-72) and 16S rRNA methylases (ArmA, RmtC and RmtF) in Nepal.2013

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Dahal RK, Mishra SK, Ohara H, Shimada K, Kirikae T, Pokhrel BM.
    • Journal Title

      Int J Antimicrob Agents

      Volume: 42 Pages: 372-374

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.2013

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Issue: 9 Pages: 4427-4432

    • DOI

      10.1128/aac.00716-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam.2013

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Kato Y, Ohmagari N, Takeshita N, Hung NV, Phuong DM, Thu TA, Binh NG, Anh NQ, Nga TT, Truong PH, Xuan PT, Thu LT, Son NT, Kirikae T.
    • Journal Title

      BMC Infect Dis

      Volume: 13 Pages: 251-251

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa2013

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57(1) Issue: 1 Pages: 96-100

    • DOI

      10.1128/aac.01105-12

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three cases of IMP-type metallo-β-lactamase-producing Enterobacter cloacae bloodstream infection in Japan.2013

    • Author(s)
      Hamada Y, Watanabe K, Tada T, Mezaki K, Takeuchi S, Shimizu T, Kirikae T, Ohmagari N.
    • Journal Title

      J Infect Chemother

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal.2013

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Dahal RK, Sah MK, Ohara H, Kirikae T, Pokhrel BM.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57(5) Issue: 5 Pages: 2394-2396

    • DOI

      10.1128/aac.02553-12

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam2013

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Kato Y, Ohmagari N, Takeshita N, Hung NV, Phuong DM, Thu TA, Binh NG, Anh NQ, Nga TTT, Truong PH, Xuan PT, Thu LTA, Son NT, Kirikae T
    • Journal Title

      BMC Infectious Diseases

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Emergence of a novel multidrug-resistant Pseudomonas aeruginosa strain producing IMP-type metallo-β-lactamases and AAC(6')-Iae in Japan.2012

    • Author(s)
      Kitao T, Tada T, Tanaka M, Narahara K, Shimojima M, Shimada K, Miyoshi-Akiyama T, Kirikae T.
    • Journal Title

      Int J Antimicrob Agents

      Volume: 39(6) Pages: 518-521

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of an immunochromatographic assay for rapid detection of AAC(6')-Ib-producing Pseudomonas aeruginosa.2012

    • Author(s)
      Tada T, Miyoshi-Akiyama T, Tanaka M, Narahara K, Shimojima M, Kitao T, Shimada K, Kirikae T.
    • Journal Title

      J Microbiol Methods

      Volume: 91(1) Pages: 114-116

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 日本の医療施設で分離されたIMP-43およびIMP-44産生多剤耐性緑膿菌2014

    • Author(s)
      多田達哉、秋山徹、切替照雄
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都江戸川区タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 日本の医療施設で分離される多剤耐性アシネトバクターバウマニーの分子疫学解析2014

    • Author(s)
      切替照雄、多田達哉、秋山徹
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都江戸川区タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] ネパールの医療施設で分離された院内感染起因菌としての多剤耐性グラム陰性菌の解析2013

    • Author(s)
      多田達哉、秋山徹、島田佳世、小原博、Pokhrel M. Bharat、切替照雄
    • Organizer
      第42回薬剤耐性菌研究会
    • Place of Presentation
      静岡県熱海市 ホテルニューさがみや
    • Related Report
      2013 Annual Research Report
  • [Presentation] 日本の医療施設で分離される多剤耐性緑膿菌株の分子疫学解析2013

    • Author(s)
      多田達哉、秋山徹、切替照雄
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2012 Research-status Report
  • [Presentation] 医療施設で分離される多剤耐性緑膿菌株の解析2012

    • Author(s)
      多田達哉、秋山徹、島田佳世、切替照雄
    • Organizer
      第41回薬剤耐性菌研究会
    • Place of Presentation
      下呂温泉 望川館 会議室
    • Related Report
      2012 Research-status Report
  • [Presentation] 日本の医療施設で分離されたIMP-43およびIMP-44産生多剤耐性緑膿菌

    • Author(s)
      多田達哉、秋山徹、切替照雄
    • Organizer
      第87回日本細菌学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本の医療施設で分離される多剤耐性アシネトバクターバウマニーの分子疫学解析

    • Author(s)
      切替照雄、多田達哉、秋山徹
    • Organizer
      第87回日本細菌学会
    • Related Report
      2013 Final Research Report
  • [Presentation] ネパールの医療施設で分離された院内感染起因菌としての多剤耐性グラム陰性菌の解析

    • Author(s)
      多田達哉、秋山徹、島田佳世、小原博、Pokhrel M. Bharat、切替照雄
    • Organizer
      第42回薬剤耐性菌研究会
    • Related Report
      2013 Final Research Report
  • [Remarks] 研究業績

    • URL

      http://www.rincgm.jp/individual/lab03/did_japanese/Publicationjp.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 業績

    • URL

      http://www.rincgm.jp/individual/lab03/did_japanese/Publicationjp.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究内容

    • URL

      http://www.rincgm.jp/individual/lab03/did_japanese/Research_Topicjp.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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