Elucidation of pathogenesis of hantavirus infection by using an animal model
| Project/Area Number |
24790433
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIMIZU Kenta 北海道大学, 医学(系)研究科(研究院), 助教 (20466840)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ハンタウイルス / 出血熱 / 病態 / 動物モデル / 糖蛋白質 / T細胞 / ケモカイン / 細胞性免疫 |
|---|
| Outline of Final Research Achievements |
Hantaviruses cause hemorrhagic fever with renal syndrome in humans. In this study, we tried to identify viral and host factors involved in pathogenesis by using a mouse model showing renal hemorrhage as in the case of patients. As a result, we found that amino acid at position 417 in viral glycoprotein Gn and host T cells are involved in the pathogenesis. In addition, we found that chemokines attracting cytotoxic T cells were significantly elevated at onset of disease, suggesting that excessive cell-mediated immunity induced by the chemokines have a role in the pathogenesis.
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Report
(4 results)
Research Products
(4 results)
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[Presentation] ハンタウイルス感染マウスモデルの開発2014
Author(s)
清水健太、吉松組子、駒貴明、有川二郎
Organizer
第79回日本インターフェロン・サイトカイン学会
Place of Presentation
北海道大学 (北海道・札幌市)
Year and Date
2014-06-19 – 2014-06-20
Related Report
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