| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Hantaviruses cause hemorrhagic fever with renal syndrome in humans. In this study, we tried to identify viral and host factors involved in pathogenesis by using a mouse model showing renal hemorrhage as in the case of patients. As a result, we found that amino acid at position 417 in viral glycoprotein Gn and host T cells are involved in the pathogenesis. In addition, we found that chemokines attracting cytotoxic T cells were significantly elevated at onset of disease, suggesting that excessive cell-mediated immunity induced by the chemokines have a role in the pathogenesis.
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