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Functional analysis of human herpesvirus 6 (HHV-6) glycoprotein Q1 (gQ1)

Research Project

Project/Area Number 24790442
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionKobe University

Principal Investigator

TANG Huamin  神戸大学, 医学(系)研究科(研究院), 助教 (10595896)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords糖タンパク / HHV-6 / トロピズム / HHV-6 / gQ1 / 機能ドメイン
Research Abstract

Human herpesvirus 6 has been reclassified as two virus species because of the huge different character of its clinical isolates. Here we focused gQ1 genes of HHV-6A and -6B, which have been reported to be important for these viruses' entry. We found that HHV-6B gQ1 could not substitute HHV-6A gQ1 function in the infection context. Furthermore, we found that the N terminal of HHV-6A gQ1 contains the site for the binding of CD46, HHV-6A entry receptor. Furthermore we also identified an amino acid residue required for HHV-6B gQ1 function.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

Research Products

(2 results)

All 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage2014

    • Author(s)
      Jasirwan, C., Furusawa, Y., Tang, H., Maeki, T., and Mori, Y.
    • Journal Title

      Microbiol Immunol

      Volume: 58(1) Pages: 22-30

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage2014

    • Author(s)
      Chyntia Jasirwan, Yoshikazu Furusawa, Huamin Tang, Takahiro Maeki, Yasuko Mori
    • Journal Title

      Microbiology and immunology

      Volume: 58(1) Pages: 22-30

    • DOI

      10.1111/1348-0421.12110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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