| Project/Area Number |
24790445
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kumamoto University |
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Principal Investigator |
MONDE Kazuaki 熊本大学, 生命科学研究部, 助教 (70516137)
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| Research Collaborator |
ONO Akira ミシガン大学, 医学部, 准教授
HARADA Shinji 熊本大学, 大学院生命科学研究部, 教授 (60173085)
MAEDA Yosuke 熊本大学, 大学院生命科学研究部, 准教授 (30284764)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | HIV-1粒子放出、感染性低下 / HERV-K Gag / 国際研究者交流 アメリカ ミシガン州 / HIV-1 / HERV-K / Gag / 共重合 / 出芽 |
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| Research Abstract |
Human endogenous retroviruses, which are remnants of ancestral retroviruses integrated into the human genome, are generally defective in viral replication. During HIV-1 infection, activation of human endogenous retroviruses have been observed in some groups. We investigated whether human endogenous retroviruses could suppress the replication of human exogenous retroviruses as HIV-1. In this study, we found that human endogenous retroviruses reduces release efficiency of HIV-1 through the coassembly between HIV-1 Gag and human endogenous retrovirus Gag. Furthermore, human endogenous retroviruses are copackaged into HIV-1 particles, and the infectivity of HIV-1 is drastically reduced by changing the morphology of HIV-1 particles.
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