| Project/Area Number |
24790449
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 感染受容体 / Saffold virus / Saffoldウイルス / SAFV |
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| Research Abstract |
The aim of the study is to identify the receptor for Saffold virus (SAFV) which is a novel human cardiovirus with unknown pathogenicity. Although 94 genes were selected as a candidate of the receptor for SAFV infection, the expression of those genes in the non-susceptible cells was unable to induce the infection of SAFV, suggesting that those genes may not be the receptor for SAFV infection. However, through the selection process, the virus binding assay demonstrated that the expression of the receptor for SAFV infection was changeable depending on the cell culture conditions. This phenomenon will be helpful to identify the receptor for SAFV infection.
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