The study on the pathogenicity of Saffold virus by means of the identification of the receptor for infection
Project/Area Number |
24790449
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Virology
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Research Institution | Kanazawa Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 感染受容体 / Saffold virus / Saffoldウイルス / SAFV |
Research Abstract |
The aim of the study is to identify the receptor for Saffold virus (SAFV) which is a novel human cardiovirus with unknown pathogenicity. Although 94 genes were selected as a candidate of the receptor for SAFV infection, the expression of those genes in the non-susceptible cells was unable to induce the infection of SAFV, suggesting that those genes may not be the receptor for SAFV infection. However, through the selection process, the virus binding assay demonstrated that the expression of the receptor for SAFV infection was changeable depending on the cell culture conditions. This phenomenon will be helpful to identify the receptor for SAFV infection.
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Report
(3 results)
Research Products
(29 results)
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[Presentation] Reverse genetics of Saffold virus2012
Author(s)
Himeda T, Okuwa T, Muraki Y, Ohara Y
Organizer
The 17th in a series of biennial meetings of the European Study Group on Molecular Biology of Picornaviruses (Europic2012)
Place of Presentation
Saint-Raphaël, France
Related Report
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[Presentation] Reverse genetics of Saffold virus.2012
Author(s)
Toshiki Himeda
Organizer
The 17th in a series of biennial meetings of the European Study Group on Molecular Biology of Picornaviruses (Europic2012)
Place of Presentation
Saint Raphael Congress Center, Saint-Raphael, France
Related Report
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