Identification of mechanisms controlling memory Th17 cell generation in steroid-resistant asthma

• Project/Area Number: 24790460
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: SUZUKI Akane 千葉大学, 医学(系)研究科(研究院), 特任助教 (90586603)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: メモリーTh17細胞 / ステロイド抵抗性喘息 / メモリーCD4 T細胞 / Th17細胞 / 喘息

Research Abstract

We identified the two candidate genes regulating memory Th17 cell generation by cDNA microarray analysis of effector cells that become memory cells. To clarify the mechanism that control memory Th17 cell generation by the candidate molecules is important for establishment of a basis for the treatment of neutrophilic and steroid-resistant Th17 dependent asthma.

Research Products

• [Journal Article] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells. (2013)
  • Author(s): Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.
  • Journal Title: Immunity Volume: 39 Issue: 5 Pages: 819-32
  • DOI: 10.1016/j.immuni.2013.09.012
  • Peer Reviewed
• [Presentation] Induction of anti-tumor effect of BCG-LM through activation of eosinophils and effector memory Th2 cells (2013)
  • Author(s): Ito, T., Hirahara, K., Suzuki, A., Shinoda, K., Hayashizaki, K., Wada, T., Yano, I., and Nakayama, T.
  • Organizer: 第42回日本免疫学会総会学術集会
  • Place of Presentation: 幕張メッセ(千葉県千葉市)
  • Year and Date: 2013-12-11
• [Presentation] The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells (2013)
  • Author(s): Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., and Nakayama, T.
  • Organizer: AAI Annual Meeting
  • Place of Presentation: Hawaii Convention Center (Honolulu, Hawaii, USA)
  • Year and Date: 2013-05-06
• [Presentation] Regulation of memory CD4 T cell pool size and function by NKT cells in vivo (2012)
  • Author(s): Iwamura, C., Endo, Y., Onodera, A., Watanabe, Y., Suzuki, A., Kinjo, Y., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2012-12-06
• [Presentation] GATA3/Ruvbl2複合体によるCdkn2c (p18, Ink4c)の転写制御を介したTh2細胞増殖制御メカニズムの解析 (2012)
  • Author(s): 細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜、中山俊憲
  • Organizer: 第22回Kyoto T cell Conference
  • Place of Presentation: 和順会館(京都府京都市)
  • Year and Date: 2012-07-07
• [Presentation] Induction of anti-tumor effect of BCG-LM through activation of eosinophils and effector memory Th2 cells.
  • Author(s): Ito, T., Hirahara, K., Suzuki, A., Shinoda, K., Hayashizaki, K., Wada, T., Yano, I., and Nakayama, T.
  • Organizer: 第42回日本免疫学会総会学術集会
  • Place of Presentation: 幕張メッセ(千葉県千葉市)
• [Presentation] The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells.
  • Author(s): Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., and Nakayama, T.
  • Organizer: AAI Annual Meeting
  • Place of Presentation: Hawaii Convention Center (Honolulu, Hawaii)
• [Presentation] Regulation of memory CD4 T cell pool size and function by NKT cells in vivo.
  • Author(s): Iwamura, C., Endo, Y., Onodera, A., Watanabe, Y., Suzuki, A., Kinjo, Y., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] GATA3/Ruvbl2複合体によるCdkn2c (p18, Ink4c)の転写制御を介したTh2細胞増殖制御メカニズムの解析
  • Author(s): 細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜、中山俊憲
  • Organizer: 第22回Kyoto T cell Conference
  • Place of Presentation: 京都
• [Patent(Industrial Property Rights)] 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物 (2013)
  • Inventor(s): 中山俊憲、細川裕之(国立大学法人 千葉大学)、常世田好司(ドイツリュウマチ研究センター)、林﨑浩史、鈴木茜(国立大学法人千葉大学)
  • Industrial Property Rights Holder: 国立大学法人千葉大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-05-30
• [Patent(Industrial Property Rights)] 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物 (2013)
  • Inventor(s): 中山俊憲、細川裕之、常世田好司、林﨑浩史、鈴木茜
  • Industrial Property Rights Holder: 国立大学法人千葉大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-114388
  • Filing Date: 2013-05-30