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The regulation of memory Th2 cell-dependent allergic airway inflammation through the IL-33-T1/ST2 pathway.

Research Project

Project/Area Number 24790461
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

ENDO Yusuke  千葉大学, 医学(系)研究科(研究院), 特任講師 (80612192)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアレルギー性気道炎症 / メモリーTh2細胞 / インターロイキン5(IL-5) / IL-33 / Eomesodermin(Eomes) / インターロイキン5(IL-5) / Eomesodermin
Research Abstract

We analyzed the effect of IL-33 on the function of memory Th2 cells. We detected IL-5 production was enhanced by culturing memory Th2 cells with IL-33. IL-33-induced IL-5 augmentation was not observed in T1/ST2-deficient memory Th2 cells. We further demonstrated the involvement of the IL-33-T1/ST2 pathway using memory Th2 cell-dependent airway inflammation models. A significant decrease in the number of inflammatory cells in the BAL fluid was observed in the T1/ST2 KO or IL-33 KO groups as compared to the WT group. We analyzed memory Th2 cells from patients with chronic rhinosinusitis and similar results were obtained to mice memory Th2 cells. These results strongly indicate that IL-33-T1/ST2-IL-5 signal could be a potential therapeutic target for treatment of chronic allergic inflammation induced by memory Th2 cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012 Other

All Journal Article (14 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Pathogenic memory type Th2 cells in allergic inflammation2014

    • Author(s)
      Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.
    • Journal Title

      Trends Immunol

      Volume: 35(2) Issue: 2 Pages: 69-78

    • DOI

      10.1016/j.it.2013.11.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells.2013

    • Author(s)
      Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.
    • Journal Title

      Immunity

      Volume: 39 Issue: 5 Pages: 819-32

    • DOI

      10.1016/j.immuni.2013.09.012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 免疫記憶の制御2013

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      臨床免疫・アレルギ−科

      Volume: 60(3) Pages: 309-316

    • NAID

      40019808031

    • Related Report
      2013 Final Research Report
  • [Journal Article] Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.2013

    • Author(s)
      Hosokawa H
    • Journal Title

      Proc Natl Acad Sci U SA

      Volume: - Issue: 12 Pages: 4691-4696

    • DOI

      10.1073/pnas.1220865110

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 免疫記憶の制御2013

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      臨床免疫・アレルギ-科

      Volume: 60 Pages: 309-316

    • NAID

      40019808031

    • Related Report
      2013 Annual Research Report
  • [Journal Article] T細胞免疫記憶—メモリ−T細胞の多様性と病因となる細胞集団—2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      臨床免疫・アレルギ−科

      Volume: 58(5) Pages: 613-620

    • NAID

      40019493231

    • Related Report
      2013 Final Research Report
  • [Journal Article] 記憶CD4 T細胞によるウイルス感染防御、アレルギ−の臨床特集2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      ウイルス感染と免疫・アレルギ−

      Volume: 436(32) Pages: 23-27

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. 109(42) : 16992-16997 (2012).2012

    • Author(s)
      Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, J. D., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 42 Pages: 16992-16997

    • DOI

      10.1073/pnas.1203494109

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenicメモリ−Th2細胞の同定とIL-5産生分子メカニズムの解明2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      医学のあゆみ

      Volume: 242(3) Pages: 266-267

    • Related Report
      2013 Final Research Report
  • [Journal Article] IL-5産生pathogenicメモリ−Th2細胞による慢性アレルギ−炎症の制御2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      実験医学別刷

      Volume: 30(6) Pages: 899-904

    • Related Report
      2013 Final Research Report
  • [Journal Article] IL-5産生pathogenicメモリーTh2相棒による慢性アレルギー炎症の制御2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      実験医学別刷

      Volume: 6 Pages: 899-904

    • Related Report
      2012 Research-status Report
  • [Journal Article] PathogenicメモリーTh2細胞の同定とIL-5産生分子メカニズムの解明2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      医学のあゆみ

      Volume: 3 Pages: 266-267

    • Related Report
      2012 Research-status Report
  • [Journal Article] 記憶CD4 T細胞によるウィルス感染防御2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      アレルギーの臨床

      Volume: 32 Pages: 23-27

    • Related Report
      2012 Research-status Report
  • [Journal Article] T細胞免疫記憶-メモリーT細胞の多様性と病因となる細胞集団-2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 5 Pages: 613-620

    • NAID

      40019493231

    • Related Report
      2012 Research-status Report
  • [Presentation] Functionally distinct Gata3/Chd4 complexes coordinately establish Th2 cell identity2013

    • Author(s)
      Hosokawa, H., Tamaki, Y., Endo, Y., Tumes, D. J., Angela. M., Sarkar, M. H., and Nakayama, T.
    • Organizer
      第42回日本免疫学会総会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2013-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Generation and maintenance of pathogenic memory CD4 T cells2013

    • Author(s)
      Nakayama, T., Endo, Y., Onodera, A., and Tumes, D. J.
    • Organizer
      The 3rd CSI/JSI/KAI Joint Symposium on Immunology
    • Place of Presentation
      Korea
    • Year and Date
      2013-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Pathogenic memory Th2 cells in the airway and regulation by activated NKT cells in vivo2013

    • Author(s)
      Nakayama, T., Iwamura, C., Shinoda, K., and Endo, Y.
    • Organizer
      第63回日本アレルギ−学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells2013

    • Author(s)
      Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., and Nakayama, T.
    • Organizer
      AAI Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2013-05-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of memory CD4 T cell pool size and function by NKT cells in vivo2012

    • Author(s)
      Iwamura, C., Endo, Y., Onodera, A., Watanabe, Y., Suzuki, A., Kinjo, Y., and Nakayama, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Generation and maintenance of memory CD4 T cells2012

    • Author(s)
      Nakayama, T., Endo, Y., Kuwahara, M., Yamashita, M., Iwamura, C., Shinoda, K., and Tokoyoda, K.
    • Organizer
      THE 34th NAITO CONFERENCE ON Infection, Immunity, and their control for Health
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells.

    • Author(s)
      Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., and Nakayama, T.
    • Organizer
      AAI Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pathogenic memory Th2 cells in the airway and regulation by activated NKT cells in vivo.

    • Author(s)
      Nakayama, T., Iwamura, C., Shinoda, K., and Endo, Y.
    • Organizer
      第63回日本アレルギ-学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Generation and maintenance of pathogenic memory CD4 T cells.

    • Author(s)
      Nakayama, T., Endo, Y., Onodera, A., and Tumes, D. J.
    • Organizer
      The 3rd CSI/JSI/KAI Joint Symposium on Immunology
    • Place of Presentation
      Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functionally distinct Gata3/Chd4 complexes coordinately establish Th2 cell identity.

    • Author(s)
      Hosokawa, H., Tamaki, Y., Endo, Y., Tumes, D. J., Angela. M., Sarkar, M. H., and Nakayama, T.
    • Organizer
      第42回日本免疫学会総会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of memory CD4 T cell pool size and function by NKT cells in vivo.

    • Author(s)
      Iwamura, C., Endo, Y., Onodera, A., Watanabe, Y., Suzuki, A., Kinjo, Y., and Nakayama, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Generation and maintenance of memory CD4 T cells.

    • Author(s)
      Nakayama, T., Endo, Y., Kuwahara, M., Yamashita, M., Iwamura, C., Shinoda, K., and Tokoyoda, K.
    • Organizer
      THE 34th NAITO CONFERENCE ON infection, Immunity, and their control for Health.
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Book] T細胞の免疫記憶、免疫学Update—分子病態の解明と治療への展開—2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report
  • [Book] 免疫学Update-分子病態の解明と治療への展開-2012

    • Author(s)
      遠藤裕介、中山俊憲
    • Publisher
      南山堂
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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