| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
FROUNT binds to the intracellular region of chemokine receptors CCR2 and CCR5, which are involved in the various inflammatory diseases. FROUNT promotes CCR2/CCR5-mediated chemotaxis by regulating PI3K/Rac/lamellipodium cascade.
In this study, we generated FROUNT-genetically modified mice. These new tools enabled us to investigate biological function of FROUNT under physiological conditions. We identified that FROUNT is highly expressed on monocytes/macrophages and regulates chemotaxis of these cells in mice. Future studies of FROUNT using these new tools in the various disease models will help us to understand the regulatory mechanisms of immune and inflammatory system.
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