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Expressional and functional analysis of FROUNT in mice

Research Project

Project/Area Number 24790462
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

TERASHIMA Yuya  東京大学, 医学(系)研究科(研究院), 助教 (90538729)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords白血球遊走 / 遺伝子改変マウス
Research Abstract

FROUNT binds to the intracellular region of chemokine receptors CCR2 and CCR5, which are involved in the various inflammatory diseases. FROUNT promotes CCR2/CCR5-mediated chemotaxis by regulating PI3K/Rac/lamellipodium cascade.
In this study, we generated FROUNT-genetically modified mice. These new tools enabled us to investigate biological function of FROUNT under physiological conditions. We identified that FROUNT is highly expressed on monocytes/macrophages and regulates chemotaxis of these cells in mice. Future studies of FROUNT using these new tools in the various disease models will help us to understand the regulatory mechanisms of immune and inflammatory system.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Identification of a binding element for the cytoplasmic regulator FROUNTin the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5.2014

    • Author(s)
      Toda E, Terashlma Y, Esakii K, Yoshinaga S, Sugihara M, Kofuku Y, Shimada I, Suwa M, Kanegasaki S, Terasawa H, Matsushima K.
    • Journal Title

      Biochemical Journal

      Volume: Vol.457 Issue: 2 Pages: 313-322

    • DOI

      10.1042/bj20130827

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍免疫学とがん免疫療法2013

    • Author(s)
      松島綱治、上羽悟史、寺島裕也
    • Journal Title

      実験医学増刊号(羊土社)

      Pages: 48-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] ケモカイン受容体CCR2, CCR5とシグナル促進分子フロント2013

    • Author(s)
      遠田悦子、寺島裕也、松島綱治
    • Journal Title

      臨床免疫・アレルギー科(科学評論社)

      Pages: 386-391

    • NAID

      40019636502

    • Related Report
      2013 Final Research Report
  • [Journal Article] ケモカイン受容体シグナル制御分子フロント(フロント)へのパラダイムシフト2013

    • Author(s)
      寺島裕也、遠田悦子、松島綱治
    • Journal Title

      がん基盤生物学

      Volume: 次世代がん研究Update Pages: 130-136

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 腫瘍会合性マクロファージ2013

    • Author(s)
      松島綱治、上羽悟史、寺島裕也
    • Journal Title

      腫瘍免疫学とがん免疫療法

      Volume: 実験医学増刊号 Pages: 48-52

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ケモカイン受容体CCR2, CCR5とシグナル促進分子フロント2013

    • Author(s)
      遠田悦子、寺島裕也、松島綱治
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 59巻 Pages: 386-391

    • NAID

      40019636502

    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of Small-Molecule Inhibitors of FROUNT2013

    • Author(s)
      寺島裕也、松島綱治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ケモカイン受容体とフロント間相互作用を阻害する低分子化合物の探索2013

    • Author(s)
      遠田悦子、寺島裕也、松島綱治, 他
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-09-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of Small-Molecule Inhibitors of FROUNT.2013

    • Author(s)
      寺島裕也
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜 神奈川県横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ケモカイン受容体CCR2/5と受容体会合分子フロントとの相互作用様式の解析2012

    • Author(s)
      遠田悦子、寺島裕也、松島綱治
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2012-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ケモカイン受容体とフロント間相互作用を阻害する低分子化合物の探索2012

    • Author(s)
      寺島裕也、遠田悦子、松島綱治, 他
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Book] がん基盤生物学「ケモカイン受容体シグナル制御分子フロント(フロント)へのパラダイムシフト」2013

    • Author(s)
      寺島裕也, 他
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.prevent.m.u-tokyo.ac.jp/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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