Novel mechanism for the regulation of lymphocyte dynamics

• Project/Area Number: 24790470
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: SUZUKI Kazuhiro 大阪大学, 免疫学フロンティア研究センター, 准教授 (60611035)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ケモカイン受容体 / シグナル伝達 / 免疫細胞動態

Research Abstract

We identified COMMD3 as a novel regulator of chemoattractant receptor signaling. In this study, we aimed at clarifying a novel mechanism for the regulation of lymphocyte dynamics through functional analysis of COMMD3. By analyzing gene-targeted mice, we found that COMMD3 acts as a positive regulator of sphingosine 1-phosphate receptor S1P1 and promotes T cell exit from the thymus.

Research Products

• [Journal Article] Subcapsular sinus macrophage fragmentation and CD169 (+) bleb acquisition by closely associated IL-17-committed innate-like lymphocytes (2012)
  • Author(s): Gray, E.E., Friend, S., Suzuki, K., Phan, T.G. and Cyster, J.G.
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Subcapsular sinus macrophage fragmentation and CD169 (+) bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. (2012)
  • Author(s): Gray, E.E., Friend, S., Suzuki, K., Phan, T.G. and Cyster, J.G.
  • Journal Title: PLoS One Volume: 7 Issue: 6 Pages: e38258-e38258
  • DOI: 10.1371/journal.pone.0038258
  • Peer Reviewed
• [Presentation] Adrenergic control of lymphocyte dynamics (2014)
  • Author(s): Kazuhiro Suzuki
  • Organizer: RIKEN IMS-JSI International Symposium on Immunology 2014
  • Place of Presentation: Yokohama(Oral presentation, Invited)
  • Year and Date: 2014-01-27
  • Invited
• [Presentation] Adrenergic conntrol of lymphocyte dynamics (2014)
  • Author(s): Kazuhiro Suzuki
  • Organizer: RIKEN IMS-JSI International Symposium on Immunology 2014
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] Adrenergic control of B cell egress from lymph nodes (2013)
  • Author(s): Kazuhiro Suzuki
  • Organizer: 42th Annual Meeting of JSI
  • Place of Presentation: Makuhari(Oral & Poster presentation)
  • Year and Date: 2013-12-13
• [Presentation] 2光子励起蛍光顕微鏡で見るB細胞免疫応答 (2013)
  • Author(s): 鈴木一博
  • Organizer: 愛媛大学分子病態医学セミナー
  • Place of Presentation: 愛媛(口頭発表)
  • Year and Date: 2013-03-13
  • Invited
• [Presentation] Adrenergic conntrol of B cell egress from lymph nodes (2013)
  • Author(s): Kazuhiro Suzuki
  • Organizer: 42th Annual Meeting of JSI
  • Place of Presentation: 幕張メッセ
• [Presentation] 2光子励起蛍光顕微鏡で見るB細胞免疫応答 (2013)
  • Author(s): 鈴木一博
  • Organizer: 分子病態医学セミナー
  • Place of Presentation: 愛媛大学
  • Invited
• [Presentation] 2光子励起顕微鏡を用いたリンパ節のイメージング (2012)
  • Author(s): 鈴木一博
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸(口頭発表)
  • Year and Date: 2012-12-07
  • Invited
• [Book] 生体イメージング研究最前線 (2014)
  • Author(s): 鈴木一博, 他
  • Publisher: 南山堂
• [Book] 生体イメージング研究最前線 (2014)
  • Author(s): 鈴木 一博 他
  • Publisher: 南山堂
• [Book] In vivoイメージング実験プロトコール (2013)
  • Author(s): 鈴木一博, 他
  • Publisher: 羊土社
• [Book] In vivoイメージング 実験プロトコール (2013)
  • Author(s): 鈴木 一博 他
  • Total Pages: 250
  • Publisher: 羊土社
• [Book] in vivoイメージング実験プロトコール (2013)
  • Author(s): 鈴木一博
  • Total Pages: 9
  • Publisher: 羊土社
• [Remarks]
  • URL: http://kazuhirosuzuki.com/
• [Remarks] Laboratory of Immune Response Dynamics
  • URL: http://kazuhirosuzuki.com/
• [Remarks] Immune Response Dynamics/Suzuki Laboratory
  • URL: http://kazuhirosuzuki.com/