| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Inflammation amplifier (IL-6 amplifier) is the key mechanism involved in chronic inflammation. In non-hematopoietic cells including fibroblasts or vascular endothelial cells, NF-kB activation together with STAT3 activation hyperactivates NF-kB signaling. Knowing the amplifier is shown to be important for the pathogenesis of autoimmune diseases or chronic graft rejection model, it is important to study the molecular basis of this mechanism, as it is a promising target for drug development. In this study, we found that ZFP1 regulates inflammation amplifier via regulating NF-kB DNA binding activity. We also identified kinase X regulating NF-kB promoter recruitment.
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