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Identification of functional relationship between the ILCs and the mast cells in the small intestine

Research Project

Project/Area Number 24790474
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

LEE YOUNGAE  大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (60610681)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsIL-22 / IL-17F / DEFAs / Innate lymphoid cells / Mast cells / Small intestine / α-defensins / Mast cell progenitors / 自然リンパ系細胞(ILC / マスト細胞前駆体 / 小腸 / マスト細胞プロテアーゼ / 細胞分化 / マスト細胞
Research Abstract

We found that the IL-7Ra+ population (CD4- LTi-like cells) within Lin-c-Kit+NKp46-CD4- cells has a protective role against bacterial infection through high expression of IL-17F and IL-22. The strong expression of DEFAs by the IL-7Ra-CD34-b7int population in the steady-state condition may play an important role in maintaining tissue homeostasis with commensal bacteria. IL-7Ra-CD34+b7int and IL-7Ra-CD34intb7hi cells are MCPs, which can differentiate into MCs that may regulate inflammatory responses by expressing high levels of MCPT5 and CPA3.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Role of Mouse and Human Autophagy Proteins in IFN-γ-Induced Cell-Autonomous Responses against Thxoplasma gondii2014

    • Author(s)
      Jun Ohshima, Youngae Lee, Miwa Sasai, Tatsuya Saitoh, Ji Su Ma, Naganori Kamiyama, Yoshiharu Matsuura, Suh Pann-Ghill, Mikako Hayashi, Shigeyuki Ebisu, Kiyoshi Takeda, Shizuo Akira, and Masahiro Yamamoto.
    • Journal Title

      The Journal of Immunology

      Volume: 192(7) Issue: 7 Pages: 3328-35

    • DOI

      10.4049/jimmunol.1302822

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal Lin-c-Kit+NKp46-CD4- Population Strongly Produces IL-22 upon IL-1β Stimulation2013

    • Author(s)
      Youngae Lee, Yutaro Kumagai, Min Seong Jang, Jung-Hwan Kim, Bo-Gie Yang, Eun-Jung Lee, You-Me Kim, Shizuo Akira, and Myoung Ho Jang
    • Journal Title

      The Journal of Immunology

      Volume: 190 Issue: 10 Pages: 5296-5305

    • DOI

      10.4049/jimmunol.1201452

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Journal of Dermatological Science2012

    • Author(s)
      Hee Jin Byun, Kwang Hyun Cho, Hee Chul Eun, Min-Jung Lee, Youngae Lee, Serah Lee, Jin Ho Chung
    • Journal Title

      Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo.

      Volume: 65 Issue: 2 Pages: 110-117

    • DOI

      10.1016/j.jdermsci.2011.12.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Intestinal Lin^-c-Kit^+NKp46^-CD4^ - population highly produces IL-22 upon IL-1βstimulation2013

    • Author(s)
      Y Lee, Y Kumagai, MS Jang, JH Kim, BG Yang, S Akira, and MH Jang
    • Organizer
      The American Association of Immunologists (AAI)
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Intestinal Lin-c-Kit+NKp46-CD4- population highly produces IL-22 upon IL-1β stimulation2013

    • Author(s)
      Youngae Lee, Yutaro Kumagai, Shizuo Akira, and Myoung Ho Jang
    • Organizer
      AAI
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intestinal mast cell progenitors function as innate lymphoid cells2012

    • Author(s)
      Y Lee, Y Kumagai, S Akira, and MH Jang
    • Organizer
      The American Association of Immunologists (AAI)
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Intestinal mast cell progenitors function as innate lymphoid cells.2012

    • Author(s)
      Youngae Lee
    • Organizer
      Immunology 2012, AAI Annual meeting
    • Place of Presentation
      Hynes Convention Center (Boston, Massachusetts, USA)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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