• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of PI3K-Akt-mTORC1 signaling pathway on Th17 differentiation

Research Project

Project/Area Number 24790479
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionTokyo Medical and Dental University (2013)
Keio University (2012)

Principal Investigator

NAGAI Shigenori  東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50348801)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsTh17 / PI3K / mTORC1 / mTORC / p70S6K / Th17分化 / Akt
Research Abstract

Th17 cell is a kind of helper T (Th) cells which causes autoimmune diseases such as rheumatoid arthritis or inflammatory bowel disease. Therefore, to clarify the molecular mechanisms of Th17 differentiation is thought to lead the effective prevention or the development of the effective therapy. In this research, we demonstrated that phosphoinositide 3-kinase (PI3K)-Akt-mTORC1 signaling pathway positively regulates Th17 differentiation.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (45 results)

All 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (34 results) (of which Invited: 2 results) Remarks (3 results)

  • [Journal Article] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.2013

    • Author(s)
      Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
    • Journal Title

      Immunity

      Volume: 39 Issue: 6 Pages: 1070-1081

    • DOI

      10.1016/j.immuni.2013.09.014

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A unique dermal dendritic cell subset that skews the immune response toward Th2.2013

    • Author(s)
      2.Murakami R, Denda-Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 9 Pages: e73270-e73270

    • DOI

      10.1371/journal.pone.0073270

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice.2013

    • Author(s)
      Yoshida H, Kotani H, Kondo T, Tani I, Wei X, Tsuruta S, Kimura A, Asakawa M, Ito M, Nagai S, Yoshimura A.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 435 Issue: 3 Pages: 378-384

    • DOI

      10.1016/j.bbrc.2013.04.096

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation2013

    • Author(s)
      Nagai S, Kurebayashi Y, Koyasu S
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1280 Issue: 1 Pages: 30-4

    • DOI

      10.1111/nyas.12059

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells.2013

    • Author(s)
      Kurebayashi Y, Nagai S, Ikejiri A, Koyasu S.
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 4 Pages: 247-265

    • DOI

      10.1111/gtc.12039

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo2012

    • Author(s)
      Sugiura D, Denda-Nagai K, Takashima M,他全7名
    • Journal Title

      PLos One

      Volume: 7 (9) Issue: 9 Pages: e44770-e44770

    • DOI

      10.1371/journal.pone.0044770

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of RORγ2012

    • Author(s)
      Kurebayashi Y. Nagai S. Ikejiri A. Ohtani M. Ichiyama K. Baba Y. Yamada T. Egami S. Hoshii T. Hirao A. Matsuda S. Koyasu S.
    • Journal Title

      Cell Reports

      Volume: 1 Issue: 4 Pages: 360-373

    • DOI

      10.1016/j.celrep.2012.02.007

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autoimmunity against M(2) muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype2012

    • Author(s)
      Yoshizawa, A.
    • Journal Title

      Eur J Immunol

      Volume: 42 Issue: 5 Pages: 1152-1163

    • DOI

      10.1002/eji.201142104

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 超音波照射はインプラント表面のバイオフィルムを除去しインプラント関連感染症(IAI)の発症を予防する2013

    • Author(s)
      吉岡研之、石井賢、永井重徳、柿沼祐亮、佐々木文、相澤守、岡田保典、小安重夫、戸山芳昭、松本守雄
    • Organizer
      第25回整形外科超音波学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a novel antimicrobial - coated biomedical polymer2013

    • Author(s)
      Ishihama H, Ishii K, Nagai S, Kakinuma H, Sasaki A, Yoshioka K, Kuramoto T, Shiono Y, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M
    • Organizer
      The International Society for the Study of Lumbar Spine (ISSLS)
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] A comparison of biofilm formation in various metal materials2013

    • Author(s)
      Yosihoka K, Ishii K, Nagai S, Kakinuma H, Kuramoto T, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M
    • Organizer
      The International Society for the Study of Lumbar Spine (ISSLS) 2013
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Propionibacterium acnes causes delayed surgical site infection only in the presence of implant2013

    • Author(s)
      Shiono Y, Ishii K, Nagai S, Kuramoto T, Yoshioka K, Ishihama H, Funao H, Kakinuma H, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M
    • Organizer
      The International Society for the Study of Lumbar Spine (ISSLS) 2013
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Cellular response of immunocyte to boron - containing apatite ceramics2013

    • Author(s)
      Nakamura M, Zhuang Z, Umeda R, Nagai S, Aizawa M
    • Organizer
      The 2nd International Symposium on Inorganic and Environmental Materials (ISIEM) 2013
    • Place of Presentation
      Rennes, France
    • Related Report
      2013 Final Research Report
  • [Presentation] The pathogenesis of pulmonary alveolar proteinosis in PI3K deficient mice2013

    • Author(s)
      Shigenori Nagai, Akihiro Yoshizawa, Yukiko Baba, Taketo Yamada, Tomoyasu Nishimura, Shigeo Koyasu
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] Resident memory T cells in epidermis require hair follicle - derived cytokines for survival2013

    • Author(s)
      Takeya Adachi, Kazuyo Moro, Shigenori Nagai, Masayuki Amagai, Keisuke Nagao
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of pulmonary alveolar proteinosis in PI3K deficient mice2013

    • Author(s)
      Akihiro Yoshizawa, Shigenori Nagai, Yukiko Baba, Tomoyasu Nishimura, Taketo Yamada, Shigeo Koyasu
    • Organizer
      The Joint International Meeting of The 78^<th> Meeting of the Japanese Society of Interferon and Cytokine Research and The 21^<st> International Symposium on Molecular Cell Biology of Macrophages 2013
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a novel antimicrobial-coated biomedical polymer.2013

    • Author(s)
      Ishihama H, Ishii K, Nagai S, Kakinuma H, Sasaki A, Yoshioka K, Kuramoto T, Shiono Y, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M.
    • Organizer
      The International Society for the Study of Lumbar Spine (ISSLS) 2013.
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] A comparison of biofilm formation in various metal materials.2013

    • Author(s)
      Yosihoka K, Ishii K, Nagai S, Kakinuma H, Kuramoto T, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M.
    • Organizer
      The International Society for the Study of Lumbar Spine (ISSLS) 2013.
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Propionibacterium acnes causes delayed surgical site infection only in the presence of implant.2013

    • Author(s)
      Shiono Y, Ishii K, Nagai S, Kuramoto T, Yoshioka K, Ishihama H, Funao H, Kakinuma H, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M.
    • Organizer
      The International Society for the Study of Lumbar Spine (ISSLS) 2013.
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cellular response of immunocyte to boron-containing apatite ceramics.2013

    • Author(s)
      Nakamura M, Zhuang Z, Umeda R, Nagai S, Aizawa M.
    • Organizer
      The 2nd International Symposium on Inorganic and Environmental Materials (ISIEM) 2013.
    • Place of Presentation
      Rennes, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] The pathogenesis of pulmonary alveolar proteinosis in PI3K deficient mice.2013

    • Author(s)
      Shigenori Nagai, Akihiro Yoshizawa, Yukiko Baba, Taketo Yamada, Tomoyasu Nishimura, Shigeo Koyasu
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Resident memory T cells in epidermis require hair follicle-derived cytokines for survival.2013

    • Author(s)
      Takeya Adachi, Kazuyo Moro, Shigenori Nagai, Masayuki Amagai, Keisuke Nagao.
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of pulmonary alveolar proteinosis in PI3K deficient mice.2013

    • Author(s)
      Akihiro Yoshizawa, Shigenori Nagai, Yukiko Baba, Tomoyasu Nishimura, Taketo Yamada, Shigeo Koyasu
    • Organizer
      The Joint International Meeting of The 78th JSICR and The 21st MMCB
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超音波照射はインプラント表面のバイオフィルムを除去しインプラント関連感染症 (IAI) の発症を予防する2013

    • Author(s)
      吉岡研之、石井賢、永井重徳、柿沼祐亮、佐々木文、相澤守、岡田保典、小安重夫、戸山芳昭、松本守雄
    • Organizer
      第25回整形外科超音波学会学術集会
    • Place of Presentation
      ウエスティンナゴヤキャッスル(愛知県名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 獲得免疫系におけるmTORC1シグナルの役割2012

    • Author(s)
      松田達志,永井重徳,星居孝之,小安重夫,平尾敦,大谷真志
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation2012

    • Author(s)
      Shigenori Nagai, Yutaka Kurebayashi, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu
    • Organizer
      Inositol Phospholipid Signaling in Physiology and Disease, New York Academy of Sciences
    • Place of Presentation
      NY,USA
    • Related Report
      2013 Final Research Report
  • [Presentation] TIM-4 blockade augments therapeutic efficacy of chemotherapy by immune-mediated mechanisms2012

    • Author(s)
      Baghdadi Muhammad, Shigeki Chiba, Hisaya Akiba, Hideo Yagita, Shigenori Nagai, Masahisa Jinushi
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Recognition of amphiphilic acylglucoside derived from Helicobacter pylori by C-type lectin receptor Mincle2012

    • Author(s)
      Masahiro Nagata, Michio Shimamura, Eri Ishikawa, Shigenori Nagai, Shigeo Koyasu, Sho Yamasaki
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] PI3K-Akt-mTORC1-S6K1/2経路はGfi1の発現およびRORの核移行を調節することによりTh17分化を制御する2012

    • Author(s)
      永井重徳,紅林泰,大谷真志,松田達志,小安重夫
    • Organizer
      第22回Kyoto T cell Conference
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 樹状細胞移入による新規コラーゲン誘導関節炎モデルの確立2012

    • Author(s)
      永井重徳,小安重夫
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of TLRs in the induction of collagen-induced arthritis2012

    • Author(s)
      Midori Iso, Shigenori Nagai, Shigeo Koyasu
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] PI3K-Akt-mTORC1-S6K経路はTh17分化を制御する2012

    • Author(s)
      永井重徳,紅林泰,池尻藍,大谷真志,馬場夕紀子,星居孝之,平尾敦,松田達志,小安重夫
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of TLRs in the induction of collagen-induced arthritis2012

    • Author(s)
      Midori Iso, Shigenori Nagai, Shigeo Koyasu
    • Organizer
      The 12th International Symposium on Dendritic Cells
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling2012

    • Author(s)
      Atsushi Anzai, Toshihisa Anzai, Shigenori Nagai, Shigeo Koyasu and Keiichi Fukuda
    • Organizer
      20th International Symposium on Molecular Cell Biology of Macrophages 2012
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] 獲得免疫系におけるmTORC1シグナルの役割2012

    • Author(s)
      松田達志,永井重徳,星居孝之,小安重夫,平尾敦,大谷真志
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation.2012

    • Author(s)
      Shigenori Nagai, Yutaka Kurebayashi, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu
    • Organizer
      Inositol Phospholipid Signaling in Physiology and Disease, New York Academy of Sciences
    • Place of Presentation
      World Trade Center Building, New York, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] TIM-4 blockade augments therapeutic efficacy of chemotherapy by immune-mediated mechanisms.2012

    • Author(s)
      Baghdadi Muhammad, Shigeki Chiba, Hisaya Akiba, Hideo Yagita, Shigenori Nagai, Masahisa Jinushi
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Recognition of amphiphilic acylglucoside derived from Helicobacter pylori by C-type lectin receptor Mincle.2012

    • Author(s)
      Masahiro Nagata, Michio Shimamura, Eri Ishikawa, Shigenori Nagai, Shigeo Koyasu, Sho Yamasaki
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Role of TLRs in the induction of collagen-induced arthritis.2012

    • Author(s)
      Midori Iso, Shigenori Nagai, Shigeo Koyasu
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] PI3K-Akt-mTORC1-S6K経路はTh17分化を制御する2012

    • Author(s)
      永井重徳,紅林泰,池尻藍,大谷真志,馬場夕紀子,星居孝之,平尾敦,松田達志,小安重夫
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Role of TLRs in the induction of collagen-induced arthritis.2012

    • Author(s)
      Midori Iso, Shigenori Nagai, Shigeo Koyasu
    • Organizer
      The 12th International Symposium on Dendritic Cells
    • Place of Presentation
      EXCO, Daegu, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling.2012

    • Author(s)
      Atsushi Anzai, Toshihisa Anzai, Shigenori Nagai, Shigeo Koyasu and Keiichi Fukuda
    • Organizer
      20th International Symposium on Molecular Cell Biology of Macrophages 2012
    • Place of Presentation
      東京大学山上会館
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mim/

    • Related Report
      2013 Final Research Report
  • [Remarks] JST,慶應義塾大学共同発表:自己免疫疾患の原因となる免疫細胞が増える新たな仕組みを発見

    • URL

      http://www.jst.go.jp/pr/announce/20120330/

    • Related Report
      2012 Research-status Report
  • [Remarks] 慶應義塾大学医学部 微生物学・免疫学教室 小安研究室 2012年研究業績

    • URL

      http://www.koyasu.umin.ne.jp/publications%202012.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi