| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
We previously reported that relapse of experimental autoimmune encephalomyelitis occurred about one week after discontinuation of FTY720, but combination treatment with FTY720 plus pathogenic autoantigen significantly suppressed occurrence of relapse. Here, we investigated the mechanism(s). We demonstrated that relapse after FTY720 alone was caused by release of autoantigen-specific T cells from secondary lymphoid tissues. Also, it was considered that the combination treatment with FTY720 plus pathogenic autoantigen might efficiently suppress relapse following discontinuation of treatment by inducing autoantigen-specific T-cell anergy.
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