Development of a novel therapy for experimental autoimmune encephalomyelitis to introduce a complete remission
| Project/Area Number |
24790483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Setsunan University |
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Principal Investigator |
YOSHIDA YUYA 摂南大学, 薬学部, 助教 (50581435)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 免疫寛容 / 自己免疫 / 自己抗原 / FTY720 |
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| Research Abstract |
We previously reported that relapse of experimental autoimmune encephalomyelitis occurred about one week after discontinuation of FTY720, but combination treatment with FTY720 plus pathogenic autoantigen significantly suppressed occurrence of relapse. Here, we investigated the mechanism(s). We demonstrated that relapse after FTY720 alone was caused by release of autoantigen-specific T cells from secondary lymphoid tissues. Also, it was considered that the combination treatment with FTY720 plus pathogenic autoantigen might efficiently suppress relapse following discontinuation of treatment by inducing autoantigen-specific T-cell anergy.
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Report
(3 results)
Research Products
(10 results)
