| Project/Area Number |
24790484
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | IgE / MyD88 / B細胞 / 肺 / アレルギー / 花粉抗原 / アレルギー・ぜんそく / IgE産生 / 喘息 / Th2応答 / 抗体産生 |
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| Research Abstract |
The production of immunoglobulin E (IgE) has a pivotal role in the development of allergic diseases including asthma. Although molecular mechanism underlying IgE class-switching in B cells has been well studied, how IgE production is induced in disease settings in our body is poorly understood. Previous studies regarding virus infection or autoimmunity reported the role of B-cell-intrinsic MyD88 signaling in Th1-type antibody responses, such as IgG2a/c production. However, the involvement of MyD88 signaling in Th2-type antibody, IgE/IgG1, responses has not been understood. Here, we studied on the IgE and IgG1 responses in intratracheally ragweed pollen exposed mice. We reveal that B-cell-intrinsic MyD88 is critical for IgE/IgG1 responses in pollen-exposed lungs in mice.
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