| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We have proposed a model of hematopoiesis in which myeloid potential is retained along with the developmental pathway towards to T, B and erythroid lineages. In this project, we aimed to validate the presence of myeloid-B progenitors on the way from multipotent progenitors towards to B cells using co-culture system with stromal cells. We found that pre-pro B cells still retain the myeloid potential while hardly maintaining T cell potential, and that proB cells terminate the differentiation potential to other lineages. These results substantiate that the myeloid-B progenitor stage exist on the differentiation pathway towards to B cells. This project has been successfully achieved.
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