Validation of the presence of myeloid-B progenitor stage towards to B cells on the differentiation pathway of hematopoiesis
| Project/Area Number |
24790486
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
MASUDA KYOKO 京都大学, 再生医科学研究所, 助教 (40565777)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫学 / 発生・分化 / 細胞・組織 / 遺伝子 |
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| Research Abstract |
We have proposed a model of hematopoiesis in which myeloid potential is retained along with the developmental pathway towards to T, B and erythroid lineages. In this project, we aimed to validate the presence of myeloid-B progenitors on the way from multipotent progenitors towards to B cells using co-culture system with stromal cells. We found that pre-pro B cells still retain the myeloid potential while hardly maintaining T cell potential, and that proB cells terminate the differentiation potential to other lineages. These results substantiate that the myeloid-B progenitor stage exist on the differentiation pathway towards to B cells. This project has been successfully achieved.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Process for immune defect ant chromosomal translocation during early thymocyte development lacking ATM2012
Author(s)
Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
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Journal Title
Blood
Volume: 120(4)
Pages: 789-799
Related Report
Peer Reviewed
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[Journal Article] Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM2012
Author(s)
Isoda T, Takagi M, Piao J, Nakagama S,Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
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Journal Title
Blood
Volume: 120(4)
Issue: 4
Pages: 789-9
DOI
Related Report
Peer Reviewed
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