Clarifying the mechanism of B cell tolerance by CIN85-mediated BCR regulation
| Project/Area Number |
24790487
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
KOMETANI Kohei 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (50437258)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 免疫寛容 / B細胞 / CIN85 |
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| Research Abstract |
To verify the possibility that adaptor molecule CIN85, which is required for transducing B Cell Receptor (BCR) signalling, have a role in the induction and maintenance of immune tolerance in B cells, I established a below experimental system.
First, I generated B cell specific CIN85-deficient mice using mb1-Cre knock in mice and flox-CIN85 mice. Second, CIN85 B cell specific deficient mice were crossed with mice those have a BCR recognising Hen Egg Lysozyme (HEL) and the mice expressing soluble HEL antigen.
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Report
(3 results)
Research Products
(4 results)
