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Clarifying the mechanism of B cell tolerance by CIN85-mediated BCR regulation

Research Project

Project/Area Number 24790487
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

KOMETANI Kohei  独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (50437258)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords免疫寛容 / B細胞 / CIN85
Research Abstract

To verify the possibility that adaptor molecule CIN85, which is required for transducing B Cell Receptor (BCR) signalling, have a role in the induction and maintenance of immune tolerance in B cells, I established a below experimental system.
First, I generated B cell specific CIN85-deficient mice using mb1-Cre knock in mice and flox-CIN85 mice. Second, CIN85 B cell specific deficient mice were crossed with mice those have a BCR recognising Hen Egg Lysozyme (HEL) and the mice expressing soluble HEL antigen.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

Research Products

(4 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation.2013

    • Author(s)
      Kometani K, Nakagawa R, Shinnakasu R, Kaji T, Rybouchkin A, Moriyama S, Furukawa K, Koseki H, Takemori T, Kurosaki T.
    • Journal Title

      Immunity

      Volume: 39 Pages: 136-147

    • DOI

      10.1016/j.immuni.2013.06.011

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] B細胞抗体産生を司る分子群の機能解明2013

    • Author(s)
      米谷耕平
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Final Research Report
  • [Presentation] Rapid plasma cell differentiation of IgG1 memory B cells2013

    • Author(s)
      米谷耕平
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Keystone, 米国
    • Related Report
      2012 Research-status Report
  • [Book] 感染・炎症・免疫2014

    • Author(s)
      米谷耕平、黒崎知博
    • Publisher
      医薬の門社
    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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